2021年1月7日 · Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac development, cardiorenal homeostasis and also implicated in …

Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation. ANP also has an anti-hypertrophic function in the heart, which is independent of its systemic blood pressure-lowering effect.

Systemically, NPs have pleiotropic roles ranging from vascular homeostasis to blood pressure regulation, natriuresis, and renin–angiotensin–aldosterone system inhibition and serve as prognostic and diagnostic markers for heart disease onset and progress.

2020年5月22日 · Important clinical entities associated with natriuretic peptide research include heart failure, obesity and systemic hypertension. Plasma levels of natriuretic peptides have proven to be powerful...

2023年12月1日 · Natriuretic peptides and their receptors are implicated in the physiological control of blood pressure, bone growth, and cardiovascular and renal homeostasis. They mediate their action through the modulation of intracellular levels of cGMP and cAMP, two second-messengers that have broad biological roles.

2024年12月25日 · Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (PubMed: 15741263 , 18835931 , 21672517 , 22307324 ).

2021年8月19日 · Cellular, biochemical, molecular, genetic, and clinical studies have facilitated understanding of the functional roles of natriuretic peptides (NPs), as well as the functions of their receptors, and signaling mechanisms in CVDs.

2015年10月27日 · Numerous studies have demonstrated the central role for NPs in regulation of blood pressure. Genetic studies in humans have suggested a role for NPs regulating cardiac hypertrophy and fibrosis, thus increasing interest in investigating NPs as targets for HF therapy.

2024年5月28日 · The natriuretic peptide system plays a fundamental role in cardio-renal homeostasis, and its potent diuretic and vasodilatory effects provide compensatory mechanisms in cardiac pathophysiological conditions and heart failure.

NPPA/atrial natriuretic peptide (natriuretic peptide type A) exerts critical pleiotropic effects in the cardiovascular system, limiting cardiomyocyte hypertrophy and death, reducing cardiac fibrosis and promoting vascular integrity.