2020年4月3日 · We established npy gene-deficient (NPY-KO) zebrafish (Danio rerio) to assess the relationship between NPY and emotional behaviours. The NPY-KO zebrafish exhibited similar growth, but pomc...

004545 129S-<i>Npy^tm1Rpa</i>/J Homozygous mutants in this <i>lacZ</i> reporter strain exhibit spontaneous and GABA induced seizures. These mice may be useful in studies related to the role of neuropeptide Y in obesity.

2025年3月6日 · 下丘脑 NPY 改善 Z24-KO 小鼠多种衰老相关症状：AAV-NPY 注射 30 天后，Z24-KO 小鼠体重显著增加，且该效果维持至 90 天，这并非由食物摄入量增加导致。

2021年6月1日 · Using NPY-KO zebrafish, this study found that the observed anxiolytic activity of NYT was independent of the NPY signaling pathway. Taken together, NYT may act as NA neurons in the expression of anxiolytic activity.

We established npy gene-deficient (NPY-KO) zebrafish (Danio rerio) to assess the relationship between NPY and emotional behaviours. The NPY-KO zebrafish exhibited similar growth, but pomc...

近日， 坎普 药物因其协同和相加作用而成为临床使用的抗抑郁药。 因此，我们使用对急性压力表现出严重焦虑反应的神经肽 Y 基因敲除 (NPY-KO) 斑马鱼评估了 Ninjinyoeito (NYT) 的抗焦虑活性。 成年 NPY-KO 斑马鱼被喂食 3% NYT 补充剂或正常饮食（即对照饮食）四天，然后通过行为测试进行检查。 在施加短期冷应激 (10 °C, 2 s) 后，对照喂养的 NPY-KO 斑马鱼表现出焦虑行为，如冻结、不稳定的运动和沿着水箱壁的游泳时间增加。 另一方面，纽约时报喂养的 NPY-KO 斑 …

2022年8月12日 · This study aimed to determine the effect of NYT on low sociality in NPY-KO zebrafish. NPY-KO zebrafish were fed a 3% NYT-supplemented diet for 4 days and subjected to behavioral tests. In the mirror test, NPY-KO zebrafish fed a control diet showed avoidance behavior toward their mirror counterparts.

Thus, we evaluated the anxiolytic activity of Ninjinyoeito (NYT) using neuropeptide Y-knockout (NPY-KO) zebrafish that exhibit severe anxiety responses to acute stress. Adult NPY-KO zebrafish were fed either a 3% NYT-supplemented or normal diet (i.e., the control diet) for four days and were then examined via behavioral tests.

2021年3月3日 · Mice that lack neuropeptide Y (NPY) or NPY receptor type 5 (NPY5R) fail to prefer food odours over pheromones after fasting, and hunger-dependent food-odour attraction is restored by...

敲除Npy基因exon 2-4，建立Npy基因敲除小鼠模型。 *使用本品系发表的文献需注明: Npy-KO mice (Cat. NO. NM-KO-190641) were purchased from Shanghai Model Organisms Center, Inc..