NR5A2 Gene - GeneCards | NR5A2 Protein | NR5A2 Antibody
2024年12月25日 · NR5A2 (Nuclear Receptor Subfamily 5 Group A Member 2) is a Protein Coding gene. Diseases associated with NR5A2 include Hepatitis B and Hepatitis. Among its related …
NR5A2 connects zygotic genome activation to the first lineage ...
2023年11月7日 · We found that NR5A2, an NR TF strongly induced upon ZGA, was required for this connection. Upon Nr5a2 knockdown or knockout, embryos developed beyond 2C normally …
生命学院颉伟课题组揭示哺乳动物基因组激活到第一次细胞命运决 …
2023年11月15日 · nr5a2在早期胚胎发育中连接基因组激活与第一次细胞命运决定. nr5a2是一个核受体家族转录因子。颉伟课题组前期研究表明发现nr5a2在zga过程中被激活，并且其dna结合 …
Nr5a2 is dispensable for zygotic genome activation but ... - Science
In vitro studies on mouse embryos have recently identified the orphan nuclear receptor NR5A2 as a key player at this developmental stage. However, although NR5A2 was initially considered …
Nucleosome-bound NR5A2 structure reveals pioneer factor …
2024年2月26日 · Nr5a2 is a key pioneer factor that regulates zygotic genome activation in totipotent embryos, pluripotency in embryonic stem cells and metabolism in adult tissues, but …
Science｜全能性先锋因子Nr5a2促进合子基因组激活 - 知乎
2022年12月7日 · 为了揭开哺乳动物中合子基因组激活的关键调控因子，德国马克斯普朗克生化研究所Kikuë Tachibana研究组在Science发表了题为Zygotic genome activation by the …
Zygotic genome activation by the totipotency pioneer factor Nr5a2
2022年11月24日 · We found that Nr5a2 binds near transcription start sites of Nr5a2-regulated ZGA genes and that binding positively correlates with the expression of target genes during …
Nuclear receptor NR5A2 controls neural stem cell fate ... - Nature
2016年7月22日 · Overexpression and loss-of-function experiments in primary NSCs and mouse embryos suggest that NR5A2 synchronizes cell-cycle exit with induction of neurogenesis and …
Nr5a2 is dispensable for zygotic genome activation but ... - PubMed
2024年10月4日 · Using mouse models of the TF Nr5a2, we show that Nr5a2-/-embryos arrest at the early morula stage and exhibit altered lineage specification, frequent mitotic failure, and …
Nr5a2 ensures inner cell mass formation in mouse blastocyst
2024年3月26日 · Recent studies have elucidated Nr5a2’s role in activating zygotic genes during early mouse embryonic development. Subsequent research, however, reveals that Nr5a2 is …