Ap1 lowered TET1 expression, and enhanced inflammation in HG-HMCs, and accentuated renal injury in DN rats. TET1 overexpression inhibited the effect of Ap1 on DN. TET1 promoted the transcription of Nrf2. The Ap1/TET1 axis mediated the Nrf2/ARE pathway activity.

2009年3月31日 · Sulfiredoxin expression is regulated by the transcription factor AP-1, which mediates its up-regulation by synaptic activity in neurons, resulting in protection against oxidative stress.

Nrf2激活剂： Curcumin 是一种天然的酚类化合物，通过激活 Nrf2 来起到化疗作用，同时为与 p300/CREB 结合的组蛋白乙酰转移酶 (histone acetyltransferase) 的抑制剂。 Bardoxolone methyl 是一种有效的 Nrf2 激活剂

The cellular signaling cascades mediated by transcription factors, including nuclear factor E2-related factor 2 (Nrf2), nuclear factor-kappaB (NF-kappaB), and activator protein-1 (AP-1), have been shown to play pivotal roles in tumor initiation, promotion, and progression processes.

2022年10月1日 · Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Ap1 / Tet1轴介导了Nrf2 / ARE途径的活动。 获得结论，Ap1抑制TET1的表达并激活DN中的Nrf2 / ARE途径，从而加剧炎症和肾脏损伤。 Cell Counting Kit (Abmole，M4839) 用来确定细胞活性。

Our study shows that AP-1 activation was attenuated by the combinations of SFN (25 μmol/L) and EGCG (20 or 100 μmol/L) in PC-3 cells. Several key Nrf2-dependent genes were down-regulated (3-fold to 35-fold) after in vivo administration of the combination of …

2022年2月15日 · Nrf2/Keap1 pathway is a key system, regulating expression of antioxidant and cytoprotective genes. Modulation of the Nrf2/Keap1 system has been proven beneficial in controlling different diseases. Electrophilic Nrf2 inducers are more advanced, but lack specificity. Direct Nrf2:Keap1 inhibitors are more specific, but face delivery concerns.

2010年8月23日 · Our study shows that AP-1 activation was attenuated by the combinations of SFN (25 μmol/L) and EGCG (20 or 100 μmol/L) in PC-3 cells. Several key Nrf2-dependent genes were down-regulated...

2009年3月1日 · We illustrate here that sulfiredoxin can be rapidly induced in vivo by administration of CDDO-TFEA, a synthetic triterpenoid inducer of endogenous Nrf2, which may offer a way of reversing peroxiredoxin hyperoxidation in vivo following chronic or …