2019年12月1日 · Moreover, nucleolin, a nuclear multifunctional protein, also binds FGF1 [58], [59] and this interaction is critical for PKCδ phosphorylation which in turn, regulates nuclear export of FGF1 to the cytosol where it is rapidly degraded [59], [61]. ... FGF2, FGF4, FGF7, FGF10, as well as FGFR1 and FGFR2 are expressed (reviewed in [105]).

2019年2月11日 · FGF7 subfamily receptor-binding specificity is further restricted by its members’ low basal FGFR-binding affinities. Notably, in FGF7, FGF10, and FGF22, a phenylalanine (Phe-83 in FGF10) replaces a highly conserved tyrosine residue in the β1 strand found in all other FGFs (Tyr-29 in FGF1) . This tyrosine – located at the center of the ...

分泌的信号成纤维细胞生长因子基于生化功能、序列相似性和进化关系可以分为一些亚科： 旁分泌 的成纤维胞生长因子的5个fgf1、fgf4、fgf7、fgf8、fgf9亚科， 内泌 的成纤维细胞生长因子的一个fgf19亚科，和 细胞内成纤维细胞生长因子 的一个fgf11亚科。

2024年12月18日 · Nucleolin and phosphorylation of FGF1 by PKCδ were reported to play a critical role in the nuclear export of FGF1 . ... FGF7 is also known as the keratinocyte growth factor, encoded on chromosome 15 q 15-21.1. The mature peptide has 194 amino acid residues. Like other members in this subfamily, FGF7 also acts in a paracrine manner solely via ...

2022年4月8日 · Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine–glycine–glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative ...

2024年9月1日 · Fibroblast growth factor 7 (FGF7), also known as keratinocyte growth factor (KGF) (Mason and Chang, 2006), is the founding member of FGF7 subfamily comprising of FGF3, FGF7, FGF10 and FGF22 (Rubin et al., 1989).It was first described by Rubin et al. as a factor stimulating epithelial cells proliferation in human (Rubin et al., 1989), and is alternatively denoted as FGF7 (Finch et al., 1995).

2019年2月12日 · The FGF7 subfamily, consisting of FGF3, FGF7, FGF10, and FGF22, is unique among FGFs in that its members are secreted exclusively by the mesenchyme, and specifically activate the "b" isoforms of FGFR1 (FGFR1b) and FGFR2 (FGFR2b) present in the overlying epithelium. This unidirectional mesenchyme-to-epithelium signaling contributes to the ...

成纤维细胞生长因子 7： 该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。这种蛋白质是一种有效的上皮细胞特异性生长因子，其促 …

2024年9月25日 · fgf7亚家族的成员对于胚胎中的器官发生和组织模式化以及介导成年哺乳动物的伤口愈合和组织稳态至关重要：fgf3是内耳发育所必需的；fgf7是肾脏、胸腺和海马体发育所必需；fgf10 用于肢体、肺、甲状腺、垂体、泪腺和唾液腺发育；fgf22负责突触前神经分化。

2024年3月15日 · Ovarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have emphasized the significant role of cancer-associated fibroblasts (CAFs) in OC development and progression. Employing sophisticated machine learning techniques on bulk transcriptomic datasets, we identified fibroblast growth factor 7 (FGF7), derived from ...