Nuclear receptor 4A1 - Wikipedia
The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 …
nur77 - 百度百科
nur77 又称为神经生长因子诱导的基因B (nerve growthfactor-induced gene B NGFI-B) 是一种细胞核孤生受体(orphan nuclear receptor) 转录因子蛋白在多种细胞的信号转导细胞周期细胞凋亡 …
Immunity（IF=43）：北大夏朋延等团队解析孤儿受体Nur77如何 …
研究人员怀疑，Nur77是胞内LPS的真正传感器。非变性凝胶电泳分析发现，与LPS孵育的Nur77迁移得比单独的Nur77慢，表明这两个分子之间存在直接结合。生物素标记的LPS可在pull-down …
孤儿核受体Nur77 作为核受体的一类,参与机体生理和病理状态下的多个过程。 Nur77可以参与细胞分化、凋亡、代谢和炎症等诸多反应,在动脉粥样硬化、骨质疏松、心肌梗死、哮喘、急性肺 …
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor …
2017年1月15日 · Nur77 is an immediate early gene whose expression is rapidly upregulated by TCR signaling in murine T cells and human thymocytes. Nur77-GFP transgenes serve as …
Nuclear receptor Nur77: its role in chronic inflammatory diseases
2021年12月17日 · Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease. The expression of Nur77 increases upon stimulation of immune cells …
Key Functions and Therapeutic Prospects of Nur77 in …
Nur77 expression and activation are rapidly induced by various physiological and pathologic stimuli. Once expressed, Nur77 initiates transcriptional activity and modulates expression of its …
Nur77: a potential therapeutic target in cancer - PubMed
These latest findings shed light on the novel roles of Nur77 as an exploitable target for new cancer therapeutics. Further work which focuses on a more complete understanding of the …
孤儿核受体Nur77在凋亡和炎症中的研究进展 - 汉斯出版社
孤儿核受体Nur77作为核受体的一类，参与机体生理和病理状态下的多个过程。Nur77可以参与细胞分化、凋亡、代谢和炎症等诸多反应，在动脉粥样硬化、骨质疏松、心肌梗死、哮喘、急性肺 …
药学院张晓坤教授团队发文Nature子刊揭示衰老相关分子机制
2021年10月15日 · 张晓坤课题组的研究，首次发现核受体 Nur77 能够通过其 N 端的无序结构区域发生相分离，并介导了损伤线粒体自噬的分子机制。