Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic …

2019年4月2日 · In this report we describe the discovery and characterization of BAY 2402234 - a novel, potent, selective and orally bioavailable DHODH inhibitor that shows monotherapy …

2024年12月24日 · DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include Developmental Dysplasia Of The Hip 1 and Developmental …

2024年11月8日 · Through bioinformatics analysis, we found that a metabolic enzyme, dihydrodiol dehydrogenase (DHDH), which is highly expressed in nonimmune-inflamed TNBC, could …

Findings: Mechanistically, DHDH mediated the synthesis and depletion of the substrate D-xylose and inhibited the activation of the proteasome subunit beta type 9 (PSMB9) and further …

2020年6月1日 · Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. …

2025年2月8日 · Survival was significantly better in gastric cancer patients with low DDH expression. Title: Overexpression of dihydrodiol dehydrogenase as a prognostic marker in …

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Keywords: Acute myeloid leukemia; Brequinar; DHODH; differentiation; metabolism; nucleotides; pyrimidines; therapeutic window.

2025年2月8日 · Clinical resource with information about DHDH, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, …