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The O-antigen is one of the most variable cell constituents, and different O-antigen forms are almost entirely due to genetic variations in O-antigen gene clusters. In this paper, we present structural and genetic evidence for a close relationship between Escherichia coli O107 and E. coli O117 O antigens.

2009年1月1日 · In this paper, we present structural and genetic evidence for a close relationship between Escherichia coli O107 and E. coli O117 O antigens.

Here, we demonstrate that supernatant from a normal E. coli isolate, FI-29, neutralizes the effect of Stx2, but not the related Stx1, on Vero cells. Biochemical characterization of the neutralizing activity identified the lipopolysaccharide (LPS) of FI-29, a serogroup O107/O117 strain, as the toxin-neutralizing component.

本研究的创新点在于首次实现了大肠杆菌o117和o107血清型o抗原重复单元的人工合成，这不仅为理解o抗原的生物合成机制提供了重要数据，还为开发针对这些病原菌的新型疫苗和抗菌药物奠定了基础。

Escherichia coli serotype O117 (ECO117) are pathogenic bacteria that produce Shiga toxin. Repeating units of the O antigen of ECO117 have the pentasaccharide structure [4-D-GalNAcβ1-3-L-Rhaα1-4-D-Glcα1-4-D-Galβ1-3-D-GalNAcα1-]n.

2009年1月6日 · The O-antigen is one of the most variable cell constituents, and different O-antigen forms are almost entirely due to genetic variations in O-antigen gene clusters. In this paper, we present structural and genetic evidence for a close relationship between Escherichia coli O107 and E. coli O117 O antigens.

2024年12月10日 · 在本工作中，WclY 的反应产物被用作途径中最终酶、L-Rha-转移酶 WclX 和 GalNAc-转移酶 WclW 的受体底物，证明了 ECO117 和 O107 重复单元的完全合成。WclX 以高度特异性转移

from publication: Identification of the two glycosyltransferase genes responsible for the difference between Escherichia coli O107 and O117 O-antigens | The O-antigen is one of the most variable...

2019年11月28日 · O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis for many serotyping schemes for Gram-negative bacteria. This review covers the diversity in E. coli O antigen structures and gene clusters, and the genetic basis for the structural diversity.