The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes .

ob是瘦素的编码基因，利用EGE技术将ob基因2、3号外显子敲除制备的B-ob/ob小鼠，具有肥胖症和高血糖症状，是研究高血糖和肥胖症的有力模型。 Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse 是在1949年 Jackson 实验室 做克隆实验时偶然发现的，属于隐形突变。 突变小鼠刚出生时在形态上与那些没受到影响的小鼠没有不同，但是在生长过程中体 …

The obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).

2021年6月28日 · Ob/ob mice are characterized by a mutation of the obese (ob) gene encoding leptin, whereas the db/db mice have a mutation of the diabetes (db) gene encoding for the ObR [20].

2016年8月10日 · Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse 是在1949年Jackson 实验室做克隆实验时偶然发现的，属于隐形突变。 突变小鼠刚出生时在形态上与那些没受到影响的小鼠没有不同，但是在生长过程中体重增加得很快，是未突变小鼠的三倍。 突变小鼠的胰岛细胞增加扩大，胰岛素水平提高，但任然会发展得高血糖。 突变的ob基因用定点克 …

This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...

This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemic ob/ob mice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance.

000632 B6.Cg- Lep ob /J Mice homozygous for the obese spontaneous mutation, Lep ob (commonly referred to as ob or ob/ob ), exhibit obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. They …

2017年9月8日 · Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. Aim of this study was to provide a micro-ultrasound (μUS) longitudinal evaluation of the ob/ob mouse...

There remains a need for robust mouse models of diabetic nephropathy (DN) that mimic key features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob leptin-deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated triglycerides, and insulin resist …