2021年8月20日 · Recent studies have highlighted the involvement of C-C motif chemokine receptor 1 (CCR1) in neuropathic pain. Herein, the current study set out to explore the modulatory role of CCR1 in spinal...

Mouse Ccr1l1 (Ccr1-like 1) encodes an orphan G-protein-coupled receptor (GPCR) with the highest homology to the inflammatory and highly promiscuous chemokine receptors Ccr1 and Ccr3 (70 and 50% amino acid identity, respectively). Ccr1l1 was first ...

2021年12月23日 · In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agonists targeting CCR1, and presented three cryogenic-electron...

使用NAMPT抑制剂FK866、TLR2抑制剂C29、CCR1抑制剂BX471、NAMPT过表达 (OE)质粒和TLR2-OE质粒进行机制研究。 结果，PAL 缓解了 ALI 的症状。 在 LPS 诱导的小鼠和 RAW264.7 细胞中，PAL 抑制 M1 表型指数并促进 M2 表型指数。 PAL 还抑制 NAMPT、TLR2、CCR1 和 NLRP3 炎性体的表达。 FK866、NAMPT-OE质粒、C29、TLR2-OE质粒和BX471处理证明PAL通过NAMPT/TLR2/CCR1发挥作用。 分子对接表明PAL可能与NAMPT结合。 总之，PAL 通过 …

2021年10月13日 · 在拟南芥中，EARLI1基因正向调节CCR1的表达，CCR1是木质素生物合成的关键酶基因(Shi et al ., 2011 )。 我们生成了 11 个PuEARLI1 - OE和 10 个PuEARLI1 -RNAi的杨树品系（图 S13）。

2025年2月6日 · In terms of mechanism, we found that blocking CCR1 could reduce the activation of NF-κB pathway and inhibit the phosphorylation of IKK, IκBα and P65. In addition, blocking of CCR1 could also reduce cartilage injury induced by macrophage conditioned medium.

2023年8月8日 · We identified that chemokine receptor-1 (CCR1) is highly expressed on monocytes (Mo) and macrophages (MΦ), and CCR1 pharmacological inhibition or CCR1 siRNA abolished lymphoma-mediated Mo/MΦ migration in a chemotaxis assay. The deficiency of host CCR1 (CCR1 KO) was associated with decreased infiltration of …

CC chemokine receptor 1 (CCR1) is found on a variety of cells in the immune system and has been shown to play an important role in the host response to pathogens. These studies used a murine model of virus-induced exacerbation of allergic airway disease to examine the role of CCR1 on T cells associa …

In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agonists targeting CCR1, and presented three cryogenic-electron...

2013年9月20日 · In this report, we show that the CC-type chemokine receptor 1 (CCR1) exhibits significant constitutive activity leading to a variety of cellular responses. CCR1 expression is sufficient to...