CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK
2021年8月20日 · Recent studies have highlighted the involvement of C-C motif chemokine receptor 1 (CCR1) in neuropathic pain. Herein, the current study set out to explore the …
Structural and functional analysis of Ccr1l1, a Rodentia-restricted ...
Mouse Ccr1l1 (Ccr1-like 1) encodes an orphan G-protein-coupled receptor (GPCR) with the highest homology to the inflammatory and highly promiscuous chemokine receptors Ccr1 and …
Identification and mechanism of G protein-biased ligands for ... - Nature
2021年12月23日 · In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agonists targeting CCR1, and …
巴马汀通过 NAMPT/TLR2/CCR1 信号传导抑制 M1 表型巨噬细胞极 …
使用NAMPT抑制剂FK866、TLR2抑制剂C29、CCR1抑制剂BX471、NAMPT过表达 (OE)质粒和TLR2-OE质粒进行机制研究。 结果，PAL 缓解了 ALI 的症状。 在 LPS 诱导的小鼠和 …
【New Phytol】PuC3H35增强根部木质素和原花青素的生物合成， …
2021年10月13日 · 在拟南芥中，EARLI1基因正向调节CCR1的表达，CCR1是木质素生物合成的关键酶基因(Shi et al ., 2011 )。 我们生成了 11 个PuEARLI1 - OE和 10 个PuEARLI1 -RNAi的杨 …
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage
2025年2月6日 · In terms of mechanism, we found that blocking CCR1 could reduce the activation of NF-κB pathway and inhibit the phosphorylation of IKK, IκBα and P65. In addition, blocking …
Blockade of CCR1 induces a phenotypic shift in ... - ScienceDirect
2023年8月8日 · We identified that chemokine receptor-1 (CCR1) is highly expressed on monocytes (Mo) and macrophages (MΦ), and CCR1 pharmacological inhibition or CCR1 …
A key role for CC chemokine receptor 1 in T-cell-mediated
CC chemokine receptor 1 (CCR1) is found on a variety of cells in the immune system and has been shown to play an important role in the host response to pathogens. These studies used a …
Expression of chemokine receptors in various cell lines. A , …
In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agonists targeting CCR1, and presented three …
(PDF) The Chemokine Receptor CCR1 Is Constitutively
2013年9月20日 · In this report, we show that the CC-type chemokine receptor 1 (CCR1) exhibits significant constitutive activity leading to a variety of cellular responses. CCR1 expression is …