Deregulation of mitochondrial sirtuins and OGG1-2a acts as a
Purpose: The present study was planned to explore the expression variations of mitochondrial sirtuins and the mitochondrial DNA repair enzyme OGG1-2a in leukemia patients. Oxidative …
Mitochondrial DNA damage, repair, and replacement in cancer
2024年10月21日 · When OGG1 was specifically targeted to mitochondria, it shielded cells from mtDNA damage, subsequently leading to HIF1α downregulation and decreased …
Loss of Mitochondrial Tumor Suppressor Genes Expression Is …
2016年1月19日 · The expression of mitochondrial tumor suppressor genes (SIRT3, SIRT4 and MTUS1), mitochondrial DNA repair gene (OGG1-2a) and a proliferation marker (Ki-67) was …
miR‐200a Modulates the Expression of the DNA Repair Protein OGG1 …
2018年3月25日 · Notably, OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes. The 8-OH-dG …
miR-200a Modulates the Expression of the DNA Repair Protein OGG1 …
2018年3月25日 · Notably, OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes. The 8-OH-dG …
Roles of DNA repair enzyme OGG1 in innate immunity and its …
The OGG1 isoform 2a mainly localizes to the mitochondria. (b) Two distinct phases of OGG1 activity on inflammatory gene promoters with the 8-oxoG lesion: I) DNA-binding and …
Decreased Mitochondrial OGG1 Expression is Linked to …
2013年6月6日 · Here, we demonstrate that SNU human hepatoma cells with declined mitochondrial respiratory activity showed decreased expression of mitochondrial 8-oxoguanine …
An active alternative splicing isoform of human mitochondrial 8 ...
2015年10月1日 · The major mitochondrial OGG1 isoform, OGG1-2a (also named β-OGG1), has also been expressed and purified; however, its activity is unresolved. Recently, we purified …
OGG1 8-oxoguanine DNA glycosylase [ (human)] - National …
OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes. The level of OGG1 expression was …
Deregulation of Mitochondrial Sirtuins and OGG1-2a Acts as a …
2021年6月30日 · Results: Significant deregulation of SIRT3 (p < 0.0001), SIRT4 (p < 0.0001), SIRT5 (p < 0.0001), Ki-67 (p < 0.0001) and OGG1-2a (p < 0.0001) was detected in patients …