Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

肝细胞生长因子（HGF），是一类由间充质细胞分泌的糖基化异源二聚体，由二硫键连接的α链（约57 kDa）和β链（约26 kDa）组成 [1]，常以非活性形式存在于多种细胞外基质中 [2]。 作为c-MET的单独配体，HGF作用于各种上皮细胞，以旁分泌方式结合并激活下游 Ras-MAPK 、 PI3K-AKT 、 STAT 、 β-链整联蛋白 和 GAB 1 等信号分子介导的各种信号传导通路，从而调节细胞生长、增殖、迁移、存活、运动和形态变化、分化等各种过程 [1]。 图1.HGF/c-MET信号通路. 成 …

2002年4月15日 · Hepatocyte growth factor (HGF), a heparin-binding factor, is synthesized as a single-chain inactive precursor (pro-HGF), which is converted by proteolysis to an active heterodimer (mature HGF). HGF has pleiotropic activities and has been implicated in the regulation of mitogenesis, motogenesis, and morphogenesis of epithelial and endothelial cells.

Why is everyone write hashtags NGFD and HGFD in posts on Instagram, in texts, on Twitter, etc.? What does it mean, what does it stand for and when to use thi...

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that promotes cell proliferation, motility, survival, and morphogenesis. HGF binds to its c-Met tyrosine kinase receptor and triggers signal transduction that protects cells against apoptosis and enhances cell …

HGF具有肝脏损伤后启动肝再生的功能，还具有显著的促细胞分裂、细胞运动及血管生成作用。 HGF刺激原代无血清培养的肝细胞DNA的合成，对多种组织器官的生长发育有重要的生理调节功能。 1.具有促进血管内皮细胞增生和新生血管形成的作用，一般认为在血管生成过程中，内皮细胞需要表现出一系列特殊、复杂的行为，包括增殖、迁移、细胞间互相黏着、排成直线以及形成开放的腔样结构，HGF刺激新生血管生成，其作用因子活性较之前更为强大。 2.可促进组织细胞的 …

2024年12月25日 · HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

2024年7月27日 · 总的来说，"OK"、"NG"和"NA"是简洁的表达方式，帮助我们在交流中快速传达对事物的评价和判断，使得沟通更加直观和高效。 理解这些缩写词的含义，能帮助我们更好地理解和回应他人的意见或反馈。 OK,NG,NA在表达意见和评价时，我们经常会遇到"OK"、"NG"和"NA"这三个缩写词。 "OK"简单明了，代表"好"，类似于英语中的"good"，表示认可或满意。 当我们.

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2002年7月31日 · In this study, we measured serum HGF concentrations of blood samples and conducted prospective studies to examine the long-term outcome of C-viral chronic hepatitis (CH) and cirrhosis in patients. The subjects examined in this study include 99 patients with C-viral CH, cirrhosis, and HCC.