2024年12月25日 · OLR1 (Oxidized Low Density Lipoprotein Receptor 1) is a Protein Coding gene. Diseases associated with OLR1 include Myocardial Infarction and Atherosclerosis. Among its related pathways are Innate Immune System and …

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene. [5] [6] LOX-1 is the main receptor for oxidized LDL on endothelial cells, macrophages, smooth muscle cells, [7] and other cell types. [8]

该基因编码属于 C 型凝集素超家族的低密度脂蛋白受体。 该基因通过环 AMP 信号通路进行调节。 编码的蛋白质结合、内化和降解氧化的低密度脂蛋白。 该蛋白可能参与 Fas 诱导的细胞凋亡的调节。 这种蛋白质可能起到清道夫受体的作用。 该基因的突变与动脉粥样硬化、心肌梗塞的风险有关，并可能改变阿尔茨海默氏病的风险。 交替剪接导致多个转录变体。 [RefSeq 提供，2010 年 2 月] This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin …

最近的研究将凝集素样 ox-LDL 受体 1 (OLR1) 的表达与肿瘤发生联系起来。 我们分析了来自 Olr1 敲除 (KO) 和野生型 (WT) 小鼠的微阵列数据中涉及细胞转化的基因，并评估了 OLR1 过表达在正常乳腺上皮细胞 (MCF10A) 和乳腺癌细胞 (HCC1143) 中基因的影响表达、迁移、粘附和 ...

TFEB-dependent autophagy is involved in scavenger receptor OLR1/LOX-1-mediated tumor progression. OLR1 is a prognostic factor and correlated with immune infiltration in breast cancer. Native and Oxidized Low-Density Lipoproteins Increase the Expression of the LDL Receptor and the LOX-1 Receptor, Respectively, in Arterial Endothelial Cells.

Oxidized low-density lipoprotein receptor 1 (OLR1) is upregulated in neurons and participates in hypertension-induced neuronal apoptosis. OLR1 deletion exerts protective effects on cerebral damage induced by hypertensive-induced stroke. Therefore, OLR1 is likely involved in the progress of intracerebral hemorrhage.

Oxidized low-density lipoprotein receptor 1 (OLR1), a key receptor for oxidized low-density lipoprotein (ox-LDL), plays a crucial role in cancer and inflammatory disease. However, the correlation between OLR1 expression and immune infiltration in breast cancer (BC) remain unclear. In this study, we …

2025年2月8日 · OLR1 may act as an oncogene by activation of NF-kB target genes responsible for proliferation, migration and inhibition of apoptosis and de novo lipogenesis genes. LOX-1 is expressed in neutrophils. LOX-1 deletion prevented neutrophil overreaction and increased neutrophil recruitment to infection sites after sepsis induction.

2024年9月19日 · 氧化低密度脂蛋白受体1（OLR1）在神经元中上调，并参与高血压诱导的神经元凋亡。 OLR1缺失对高血压性脑卒中引起的脑损伤具有保护作用。 因此，OLR1可能参与了脑出血的进展。 在这项研究中，我们使用大鼠模型检测了OLR1在脑出血中的潜在作用。 将OLR1小干扰RNA（10μL；50pmol/μL）注射到右侧基底节以敲除OLR1。 24小时后，注射0.5U的VII型胶原酶以诱导脑出血。 我们发现，敲低OLR1可以减轻脑出血大鼠的神经行为障碍，并减少大鼠脑组织 …

In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).