2023年5月22日 · Herein, we report bacterial outer membrane vesicles (OMVs)-encapsulating Ads as microbial nanocomposites that are engineered for autophagy-cascade-augmented immunotherapy. Biomineral shells cover...

2023年8月14日 · In particular, Gram-negative bacteria produce specific vesicles with a single lipidic layer called OMVs (Outer Membrane Vesicles). These vesicles exhibit remarkable capabilities, such as disseminating throughout the entire organism, transporting toxins, and being internalized by eukaryotic cells.

2024年2月1日 · RNA-seq showed that Fn OMVs activate intracellular autophagy pathways. Blocking autophagic flux with CHQ not only reduced Fn OMV-induced cancer cell migration in vitro and in vivo but also reversed the expression changes in EMT-related proteins. Metastasis is an important cause of high mortality and lethality of oral cancer.

2025年2月10日 · Outer membrane vesicles derived from Pseudomonas aeruginosa (PA-OMVs) play a crucial role in bacterial pathogenesis, mediating immune modulation and inflammation. Autophagy, a process that degrades damaged organelles, and pyroptosis, a form of programmed cell death, both regulate immune responses and contribute to infection defense.

2019年2月19日 · We found that AMPK signaling relieves mTORC1-mediated repression of the autophagy pathway in response to infection, positioning the cell for a rapid induction of autophagy. Moreover, activation of AMPK and inhibition of mTORC1 in response to bacteria is not accompanied by an induction of bulk autophagy.

2019年5月23日 · Treatment of cells with purified OMV results in activation of AMPK and inhibition of MTORC1, and pre-treatment of OMV before infection can enhance xenophagy. These experiments show that OMV-detection triggers a priming response, pre-activating the autophagy kinases in case of bacterial invasion (

2014年9月4日 · Our results indicate that the OMVs architecture might play a role in stability of VCC and thereby can enhance its biological activities in comparison with the free secreted VCC. Furthermore, we tested the role of OMV-associated VCC in host cell autophagy signalling using confocal microscopy and immunoblot analysis.

Because autophagy and inflammation are crucial in the host’s response to infection especially during sepsis, our findings revealed an unsuspected role of OMVs in the crosstalk between bacteria and their host, highlighting the fact that these extracellular vesicles have exacerbated pathogenic properties.

2015年5月15日 · Outer membrane vesicles (OMVs) are bacterial nanoparticles that are naturally produced during bacterial growth both in vitro and in vivo. OMVs can interact with...

2023年8月14日 · OMV toxins can target mitochondria by direct or indirect delivery. Entire OMVs derived from Neisseria gonorrhoeae have been shown to interact with mitochondria allowing the direct delivery of the toxin PorB, known to induce cytochrome C release and apoptotic cell …