2023年4月17日 · We demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable complexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic properties. Such OMV-Dye complexes are biodegradable and …

2023年8月14日 · 监测单次静脉注射(×1)或多次静脉注射(×3， ×5)给药的Cyanine7 (Cy7)标记的OMV在肿瘤中的积累，其中只在最后一次注射中使用 Cy7标记 的OMV。 虽然在×1组中标记的OMV确实在肿瘤部位积聚，但标记的OMV在肿瘤部位发出信号在×3和×5组逐渐减少。

2025年2月14日 · In this study, bone marrow-derived mesenchymal stem cells (BMSCs) are genetically engineered to overexpress CXCR4 and isolated cell membranes (mBMSC CXCR4) for hybridization with OMVs derived from Escherichia coli (E. coli) to produce nanovesicles (mBMSC CXCR4 @OMV).

Nevertheless, emerging evidence reflected shortcomings of native OMV in tumor therapy recently. Kim et al. labeled OMVs with Cyanine7 (Cy7) and detected different levels of OMVs aggregation in the GI tract, liver, and heart, even though the highest signal was detected in tumor sites 12 hours after intravenous injection (Figure 2B-C). Native ...

2017年9月20日 · Cy7-labeled OMVs (10 μg in total protein) were injected intravenously to normal mice and mice bearing tumor with a diameter of 15 mm (male, 8 weeks old).

2022年5月2日 · Here we show that outer membrane vesicles (OMVs) fused to a tumour antigen and produced in the intestine by ingested genetically engineered bacteria function as effective tumour vaccines in mice.

We demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable com-plexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic properties. Such OMV-Dye complexes are biodegradable and safe for in vivo applications.

2023年8月15日 · 开发了一种装载PD-1质粒的LyP1多肽修饰的外膜囊泡 (LOMV)，以实现PD-L1在肿瘤细胞中的自阻断。 纳米载体通过OMV靶向能力在肿瘤组织中积累，并通过lyP1介导的靶标内化到肿瘤细胞中，随后将PD-1质粒传递到细胞核中，导致肿瘤细胞表达PD-1。 同时，LOMV的外膜蛋白向肿瘤组织招募细胞毒性淋巴细胞和自然杀伤细胞，刺激其分泌IFN-γ，提高PD-1/PD-L1通路阻断治疗的抗肿瘤活性。 模型：4T1乳腺肿瘤. 未明确写OMV用量，未看到OMV体内生物毒 …

Targeting of E. coli ΔmsbB OMVs to tumor tissues after systemic administration. a Cy7 control and Cy7-labeled E. coli ΔmsbB OMVs (ΔmsbB Cy7 OMVs) were systematically injected to BALB/c mice...

2021年4月6日 · Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are qualified as immunoadjuvants. Here, we describe a versatile OMV-based vaccine platform to...