2024年4月3日 · In liposomes, we captured the fully open structure of OSCA1.2 in the inside-in orientation, in which the pore shows a large lateral opening to the membrane. Unusually for ion channels,...

OSCA (OmicS-data-based Complex trait Analysis) is a software tool for the analysis of complex traits using multi-omics data and genetic analysis of molecular phenotypes. Functions currently...

2014年8月27日 · Here we describe a hyperosmolality-gated calcium-permeable channel and its function in osmosensing in plants. Using calcium-imaging-based unbiased forward genetic screens we isolated Arabidopsis...

2014年10月16日 · OSCA1 represents a channel responsible for [Ca(2+)]i increases induced by a stimulus in plants, opening up new avenues for studying Ca(2+) machineries for other stimuli and providing potential molecular genetic targets for engineering drought-resistant crops.

2018年11月29日 · Here, we present the structure of OSCA1.2 from Arabidopsis thaliana (AtOSCA1.2) determined by single-particle cryo-electron microscopy (cryo-EM) with a nominal resolution of 3.68 Å for the...

2022年5月1日 · How can Ca 2+ can acts as both promoter and attenuator of root hydrotropism? In case of CO 2 concentration-dependent stomatal aperture regulation, it has been shown that cytosolic Ca 2+ elevation can participate in both stomatal opening and closure, producing different Ca 2+ signatures in the guard cells (Young et al., 2006).

Here we show that two members of the OSCA protein family in Arabidopsis thaliana, namely AtOSCA1.1 and AtOSCA3.1, belong to a new class of mechanosen-sitive ion channels. We solve the structure...

植物通过感受器感知外界的环境变化,OSCA1是植物中鉴定到的第一个渗透胁迫感受器,但是目前为止,对植物如何感受环境中的渗透胁迫以及响应的研究仍有很多疑惑.蛋白质形成二聚体发挥功能是一种非常普遍的现象,探究OSCA家族成员形成同/异源二聚体对其生物学 ...

研究团队结合生化实验和定量磷酸化蛋白质组学技术，揭示了拟南芥钙离子渗透通道OSCA1.3控制免疫信号传导期间气孔关闭的机制。 中文标题： 钙离子渗透通道OSCA1.3调节植物气孔免疫. 研究对象： 拟南芥. 发表期刊： Nature. 影响因子： 42.778. 单位： 东英吉利大学. 发表时间： 2020年08月. 主要运用生物技术： 定量磷酸化蛋白质组学. 研究方法及结果. 在 模式植物 拟南芥中，质膜相关的胞质激酶BIK1充当多个细胞表面免疫受体下游的中央 免疫调节剂。

2015年10月26日 · Hyperosmolality-gated calcium-permeable channels (OSCA) were first characterised as an osmosensor in Arabidopsis and are involved in the perception of extracellular changes to trigger hyperosmolality-induced [Ca 2+] i increases (OICI).