骨膜蛋白(POSTN)检测 - 知乎 - 知乎专栏
Periostin （POSTN、PN或成骨细胞特异性因子OSF-2）是一种蛋白质，由POSTN基因编码。 Periostin作为α-V/β-3和α-V/β-5整合素的配体，支持上皮细胞的粘附和迁移。 骨胶原蛋白 是一种釉质结构的维生素K依赖性因子，它是一种分泌型细胞外基质蛋白，最初在间质系细胞（成骨细胞、成骨细胞衍生的细胞、牙周韧带和骨膜）中被发现。 它与癌症中的 上皮-间质转化 以及发育中的心脏中的间质分化有关。 该蛋白与昆虫中的分泌型细胞粘附分子Fasciclin I有同源性。 在许多癌 …
骨膜蛋白—一种有潜力的疾病早期诊断分子标志物
骨膜蛋白(periostin，POSTN)，也称osteoblast-specific factor OSF-2和PDLPN，是一种分泌型细胞外基质蛋白，也是gla域维生素K依赖性因子 ，在人体中由POSTN基因编码，位于人类13号染色体13q13.3，在小鼠中位于3号染色体3|3 C。人源POSTN蛋白由836个氨基酸组成，分子量约 …
Periostin: an emerging activator of multiple signaling pathways
As a non-structural matricellular protein, POSTN, also called osteoblast-specific factor-2 (OSF-2), was originally cloned from the mouse preosteogenic cell line MC3T3-E1, without the fibroblast cell line NIH3T3 (Horiuchi et al. 1999; Takeshita et al. 1993). With a molecular weight of 90 kDa, POSTN contains an N-terminal secretory signal peptide ...
Identification and characterization of a novel protein ... - PubMed
We had previously identified the cDNA for a novel protein called osteoblast-specific factor 2 (OSF-2) from an MC3T3-E1 cDNA library using subtraction hybridization and differential screening techniques. Here we describe the localization, regulation, and potential function of this protein.
Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is
2019年8月13日 · Osteoblast-Specific Factor 2 (OSF-2, Periostin) is a secreted extracellular matrix protein (ECM) expressed in fibroblasts during bone and teeth development. Expression of OSF-2 has been also related to the progression and drug resistance of different tumors.
Mouse Periostin/OSF-2 Isoform 2 Antibody - R&D Systems
Mouse Periostin, also known as OSF-2 (osteoblast-specific factor 2) is a 170 kDa, secreted, homodimeric protein that belongs to the periostin family of the FAS1 superfamily of molecules (1‑4). It is a TGF-beta inducible molecule that serves as both an adhesion molecule and tumor suppressor (2, 5, 6, 7).
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Periostin/OSF-2 Antibody - C-terminus - Azide and BSA Free
View knockout-validated Rabbit Polyclonal anti-Periostin/OSF-2 Antibody - C-terminus - Azide and BSA Free (NBP1-30042). Validated Applications: WB, ICC/IF, IHC, KO. Validated Species: Human, Mouse, Rat + more.
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人骨膜蛋白(POSTN/OSF-2)酶联免疫吸附测定试剂盒-瑞迪生物科技…
依次加入生物素化的抗人POSTN/OSF-2抗体和辣根过氧化物酶标记的亲和素。 抗人POSTN/OSF-2抗体与结合在包被抗体上的人POSTN/OSF-2结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。 加入显色底物 (TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。 用酶标仪在450nm波长处测OD值，人POSTN/OSF-2浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中人POSTN/OSF-2的浓度。 由于实验操作条件的不同 (如操 …
Recombinant Human Periostin/OSF-2 Protein, CF - R&D Systems
Periostin, also known as OSF-2, is a secreted matricellular protein with functions in extracellular matrix formation, cell migration, and inflammation (1). It is secreted as a 90 kDa monomer that can aggregate into >170 kDa higher-order multimers (2). Periostin contains an N-terminal EMI domain followed by four tandem FAS1 domains (3).
Periostin: An Emerging Molecule With a Potential Role in Spinal ...
2021年8月26日 · Periostin (POSTN), an ECM protein, is the first adhesion molecule identified in the mouse osteoblast cell line MC3T3-E1, and is also called osteoblast-specific factor 2 (OSF-2). It is closely homologous to the insect cell adhesion molecule Fasciclin 1 .