To better understand how EBNA1 controls these processes, we have assessed the contribution of various EBNA1 sequences to its replication, segregation, and transactivation functions. Here …

Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA1) is an essential viral protein and is expressed in all EBV-associated tumours as well as all latency programs of the virus, except perhaps for …

Assays for EBV serostatus assess antibody to both EBV viral capsid antigen (VCA) and Epstein-Barr nuclear antigen-1 (EBNA-1), but PTLD risk among SOT recipients with discordant VCA …

2018年4月6日 · EBNA1 is essential for viral genome maintenance and also for controlling viral gene expression and without EBNA1, the virus cannot persist. EBNA1 itself has been linked to …

2024年10月10日 · In this proof-of-concept study, we employed a structure-based design strategy to create three unique immunogens specifically targeting the DNA binding state of the EBNA1 …

We show that EBNA-1 induces chromosomal aberrations, DNA double-strand breaks, and engagement of the DNA damage response (DDR). These signs of genomic instability are …

2020年3月19日 · 在一般的SN2亲核取代中，做为离去基团Br，I，Cl，OMs，OTf，OTs之间离去能力的比较？

2021年2月3日 · 近日，来自美国费城威斯达研究所的 Paul M. Lieberman 研究组在 Cell 杂志上发表了一篇题为 Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination …

EBNA-1是EBV潜伏感染时编码的一种核蛋白,它能调节EBV基因的复制,增强病毒基因的转录,并能保证EBV以附加体的形式稳定存在于被感染的细胞内。 利用此蛋白上述两种功能特点,研究者构 …

Here, we provide a general overview of the EBNA3 genes and proteins. In particular, we describe recent research that has highlighted the complexity of their functional interactions with each …