2007年9月15日 · Although OX40L ligand (OX40L) is thought to play a key role in Th2 development, the critical cellular source of this molecule has yet to be identified. In this study, we demonstrate that OX40L expression by the initiating dendritic cell (DC) is a fundamental requirement for optimal induction of primary and memory Th2 responses in vivo.

2020年3月20日 · The T cell co-stimulatory molecule OX40 and its cognate ligand OX40L have attracted broad research interest as a therapeutic target in T cell-mediated diseases. Accumulating preclinical evidence highlights the therapeutic efficacy of both agonist and blockade of the OX40-OX40L interaction.

OX40信号可以促进CD4和CD8 T细胞的存活，维持抗凋亡蛋白表达（BCL-XL、BCL-2和BFL1），增强IL-2、IL-4、IL-5和IFN-g的细胞因子产生，增强肿瘤效应T细胞的免疫应答，并增强肿瘤特异性记忆T细胞的产生。 5、OX40临床研发进展——肿瘤领域开发终止 自免领域好消息频传. 下图为OX40/OX40L进入临床阶段的管线情况（需要完整表格可加微信获取），标黄部分为终止项目，适应症主要为肿瘤： OX40在肿瘤领域而言，辉瑞、罗氏等巨头终止了OX40激动剂的 …

GA may exert a therapeutic effect on OVA-induced experimental asthma partly by regulating the Th1/Th2 balance through suppressing OX40-OX40L signalling and p38 MAPK activity.

2024年12月30日 · OX40L通过激活OX40信号通路，促进Th2等辅助性T细胞的活化，上调促炎细胞因子的产生，从而促进炎症的发生。 OX40/OX40L是特异性皮炎（AD）的一个有希望的治疗靶点。

OX40L通过激活OX40信号通路，促进Th2等辅助性T细胞的活化，从而促进炎症的发生。 因此，OX40和OX40L也有望成为特应性皮炎（AD）等治疗的一个新靶点。

2020年3月1日 · OX40–OX40L signals can enhance the Th1-mediated immune response, promote generation and maintenance of Th2, favor Th9 differentiation through the non-canonical NF- κ B pathway, augment Tfh development, and antagonize …

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the TNFR/TNF superfamily and are expressed on activated CD4 and CD8 T cells as well as a number of other lymphoid and non-lymphoid cells.

2006年2月23日 · OX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 Å, respectively.

OX40L is a costimulatory molecule that plays a sentinel role in the adaptive immune response by promoting T helper (Th) 2 polarization of naive T cells within the lymph node. These polarized T cells produce Th2 cytokines such as IL-4, IL-5, and IL-13, which have been implicated particularly in allergic eosinophilic asthma.