2024年12月25日 · OAS1 (2'-5'-Oligoadenylate Synthetase 1) is a Protein Coding gene. Diseases associated with OAS1 include Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia and Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia.

2018年12月27日 · We performed comprehensive phylogenetic and functional analyses of OAS genes from evolutionarily lower to higher Metazoa to demonstrate how the OAS repertoires have developed anti-viral activity and diversified their functions.

2019年3月1日 · We show for the first time that OAS1, 2 and 3 restrict intracellular pathogenic mycobacterial replication and enhance pro-inflammatory cytokine secretion. Recent evidence suggests largely unifying pathways with regards to sensing and responding to …

2018年12月27日 · Upon double-stranded RNA (dsRNA) binding, avian and mammalian OASs generate the second messenger 2'-5'-linked oligoadenylate (2-5A), which activates ribonuclease L (RNaseL) and blocks viral replication. However, how Metazoa shape their OAS repertoires to keep evolutionary balance to virus infection is largely unknown.

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis.

2',5'-Oligoadenylate synthetases (OASs) belong to the nucleotidyl transferase family together with poly(A) polymerases, CCA-adding enzymes and the recently discovered cyclic-GMP-AMP synthase (cGAS). Mammalian OASs have been thoroughly characterized as components of the interferon-induced antiviral s …

The 2′-5′-oligoadenylate synthetases (OASs) are members of a family of interferon-induced proteins playing an important role in the antiviral effect of interferons as well as being involved in apoptosis and control of cellular growth.

2018年9月17日 · OASs gene expression could be induced by infiltrating monocytes, activation by dsRNA viruses, or by necrotic/apoptotic events in muscle myositis. Moreover, the activation of IFNs pathway induced by viral infections could represent the link between the upregulation of both the OAS gene family and the dsRNA virus network that we observed in our ...

2023年1月6日 · The oligoadenylate synthesis (OAS) gene family, which is an important component of the immune system, provides an essential response to the antiviral activities of interferons by regulating immune signal pathways. However, little is known about the evolutionary characteristics of OASs in Laurasiatherian mammals.

2019年2月1日 · The IFN-induced 2′,5′-oligoadenylate synthetases (OASs) have been identified as a member of the ISGs family characterized by the ability to synthesize 2′,5′-oligoadenylate (2-5A), which can induce the degradation of viral RNA by activating RNase L within the infected cells to block viral replications.