2020年6月16日 · Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human...

2021年11月30日 · PRF 信号是嵌入在 mRNAs 中的顺式作用元件，随机地将核糖体翻译到一个新的阅读框中（即 +1 或 − 1 核苷酸）。 在典型的病毒环境中，PRF 信号允许核糖体绕过框终 …

2019年5月10日 · Ornithine decarboxylase (ODC), a key enzyme in this process, is degraded by ornithine decarboxylase antizyme (OAZ). Synthesis of OAZ requires a +1 PRF event that is …

2024年2月1日 · Down-regulation of the titration of OAZ via AZIN leads to enhanced degradation of OAZ-targeted ODC, reducing ODC, inhibiting putrescine synthesis, and suppressing further …

2016年2月19日 · Programmed −1 ribosomal frameshifting (−1 PRF) has been identified as a mechanism to regulate the expression of many viral genes and some cellular genes. The …

2011年9月7日 · Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines, is regulated by an antizyme (OAZ). Polyamines induce antizyme expression by …

2018年4月2日 · OAZ +1 PRF is autoregulated by the availability of small molecules in the form of polyamines (i.e., the products of the synthetic pathway controlled by OAZ). OAZ …

The results showed that eIF5A is a trans-regulator of +1 PRF for Ty1 retrotransposon and could function universally in yeast. View PRF at the shifty site derived from the OAZ1 in S. cerevisiae...

2014年1月1日 · Polyamine-regulated synthesis of OAZ involves a ribosomal frameshifting event at an internal STOP codon of OAZ mRNA. OAZ forms inactive ODC/OAZ heterodimers, in …

2023年12月15日 · Our results show the expanded function of the CRISPR-Cas12 system in modulating −1 PRF efficiency through stalling ribosomes and deforming frameshifting …