NARF is a hypoxia-induced coactivator for OCT4-mediated
2022年12月9日 · To investigate the role of NARF in OCT4-mediated transcription, we generated OCT4-KD subclones of MDA-MB-231 cells by stable transduction with lentiviral vectors …
Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 …
2012年4月6日 · Here, we identify general and cell-line-specific requirements for NANOG, OCT4, and SOX2 in hESCs. We show that OCT4 regulates, and interacts with, the BMP4 pathway to …
Silencing of the transcription factors Oct4, Sox2, Klf4, c-Myc or …
2019年9月17日 · Silencing of Oct4, Sox2 and Klf4 generate mainly teratomas with mesoderm tissue. Silencing of Yamanaka Factors does not affect p19 teratoma growth in vivo. Induced …
Pioneer and PRDM transcription factors coordinate bivalent …
2024年1月10日 · To address the interplay between pioneer TFs and epigenetic regulatory mechanisms during cell differentiation, we investigated the role of FOXA in human endoderm …
Post-translational modification of OCT4 in breast cancer ... - Nature
2018年3月6日 · Ubiquitination-defective mutant of OCT4 (K284R) overexpressed cells drastically generated tumor burdens in mice. Patients with breast cancer who showed low CHIP …
OCT4 expression transactivated by GATA protein is ... - Cell Press
2022年11月22日 · Then, to test whether the prolonged OCT4 expression in porcine early TE is meaningful or just an inconsequential process, we used the lentivirus-based TE-specific OCT4 …
Oct4——胚胎干细胞多能性的守门人 - 华美生物
2023年11月1日 · Oct4是ESCs中的一个重要转录因子，在维持ESCs的多能性和自我更新能力方面发挥着关键作用。 Oct4通过激活多能性基因并抑制分化基因的表达，使ESCs保持自我更新和 …
Roles of OCT4 in tumorigenesis, cancer therapy ... - ScienceDirect
2016年12月1日 · OCT4 enhances tumorigenesis and progression of different types of cancer. Therapy-resistant cells present higher levels of OCT4 than sensitive ones. OCT4 correlates …
Spatiotemporal dynamics of OCT4 protein localization during ...
2016年11月1日 · In this study, we revealed that OCT4 protein localization was markedly altered during the epigenetic reprogramming phases after fertilization. Furthermore, exogenous Oct4 …
Distinct Lineage Specification Roles for NANOG, OCT4
2012年4月6日 · Here, we identify general and cell-line-specific requirements for NANOG, OCT4, and SOX2 in hESCs. We show that OCT4 regulates, and interacts with, the BMP4 pathway to …