2025年3月15日 · Understanding FapC reveals how Pseudomonas exploits functional amyloids for biofilm formation and establishes a structural and mechanistic foundation for developing …

2020年3月27日 · Here, we provide structural information and mechanistic data for fibrillation of the smallest amyloidogenic truncation unit along with the full-length version (FL) of the major …

FA from different bacteria, including Escherichia coli (CsgA) and Pseudomonas (FapC), contains a number of imperfect repeats which may be key to efficient aggregation. Here we report on …

2023年1月30日 · The main amyloid forming protein in Fap is FapC, which has a mass of 23.6 kDa and whose three repeat regions of 37 amino acids (R1, R2 and R3) are predicted by co …

2022年1月1日 · The general aggregation inhibitor epigallocatechin gallate (EGCG) inhibits FapC fibrillation by blocking interactions between FapC and vesicles and redirecting FapC …

FapC 和 FapB 是与生物膜相关的淀粉样蛋白，与假单胞菌和其他细菌的毒力有关。 我们在此证明了它们卓越的热和化学弹性，表明生物膜结构可以承受标准灭菌，从而有助于铜绿假单胞菌感 …

While much is known about CsgA biogenesis and fibrillation, the mechanism of FapC fibrillation remains less explored. Here, we show that removing the three imperfect repeats of FapC …

Functional amyloid (FA) proteins have evolved to assemble into fibrils with a characteristic cross-β structure, which stabilizes biofilms and contributes to bacterial virulence. Some of the most …

2018年10月12日 · FapC protein from P. aeruginosa makes amyloid fibrils which strengthen biofilm. We identify hexapeptide repeat sequences implicated in FapC amyloid formation. …

2017年8月15日 · We adapted this system to test mutant operons for secretion. Secreted FapC is rapidly transformed into the amyloid state outside the cell, whereas intracellular FapC remains …