Nature Metabolism丨巨噬细胞响应脂多糖和干扰素-γ刺激的两阶 …
The metabolic transition into the late stage is largely driven by the inhibition of the pyruvate dehydrogenase complex (PDHC) and the oxoglutarate dehydrogenase complex (OGDC), …
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid ...
2022年10月20日 · Here, we report a novel mechanism capable of substantially inhibiting PDHC and OGDC: reactive nitrogen species (RNS) can covalently modify the thiols on their lipoic …
Two-stage metabolic remodelling in macrophages in response to ...
The metabolic transition into the late stage is largely driven by the inhibition of pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which is …
Two-stage metabolic remodelling in macrophages in response to …
2019年7月12日 · The metabolic transition into the late stage is largely driven by the inhibition of the pyruvate dehydrogenase complex (PDHC) and the oxoglutarate dehydrogenase complex …
Reactive nitrogen species inhibit branched chain alpha-ketoacid ...
2023年7月31日 · We found that TNF-α and IFN-γ stimulated NO production in myotubes and myoblasts lead to significant inhibition of BCKDC, PDHC, and OGDC, and altered energy …
Hypoxia inducible factor-1α is an important regulator of …
2023年6月1日 · Pyruvate dehydrogenase kinase isozyme 1 (PDK1) inhibits pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), thereby …
一氧化氮驱动的硫辛臂修饰抑制α-酮酸脱氢酶,Nature Chemical …
我们发现 RNS 介导的 PDHC 和 OGDC 抑制发生在经典巨噬细胞激活过程中，随着时间的推移，驱动细胞代谢的显着重新连接。 这项工作提供了 RNS 和线粒体代谢之间的新机制联系，与 …
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid ...
We found RNS-mediated inhibition of PDHC and OGDC occurs during classical macrophage activation, driving significant rewiring of cellular metabolism over time. This work provides a …
Nitrosylation rewires metabolism - Nature Chemical Biology
2022年10月20日 · They confirmed that nitrosylation of lipoate impairs PDHC and OGDC activity using nitric oxide (NO) donors in vitro, and showed that RNS result in a diverse range of …
2022年1月31日 · Mitochondrial -ketoacid dehydrogenases, including the pyruvate dehydrogenase complex (PDHC) and the oxoglutarate dehydrogenase complex (OGDC), are a family of multi …