Dec 25, 2024 · OGDHL (Oxoglutarate Dehydrogenase L) is a Protein Coding gene. Diseases associated with OGDHL include Yoon-Bellen Neurodevelopmental Syndrome and Seckel Syndrome. Among its related pathways is 10q11.21q11.23 copy number variation syndrome.

该基因编码的蛋白质类似于 OGDH 复合物中的氧化戊二酸脱氢酶 (OGDH) ，可降解葡萄糖和谷氨酸。 该基因编码几种亚型，包括一些似乎定位于线粒体的亚型。 编码的蛋白质下调 Akt 信号级联，可以抑制宫颈癌细胞的生长。 [RefSeq 提供，2016 年 12 月] The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) …

氧化戊二酸脱氢酶(ogdhl)是氧化戊二酸脱氢酶(ogdh)复合体中降解葡萄糖和谷氨酸的同工酶。 据报道，OGDHL可以重新编程 谷氨酰胺 代谢，以酶活性依赖的方式抑制肝癌的进展。

本综述系统地介绍了OGDHL的机制及在不同疾病中的表达情况和作用。 氧戊二酸脱氢酶样（oxoglutarate dehydrogenase-like，OGDHL）蛋白是氧戊二酸脱氢酶复合体(OGDHC)的主要限速亚基之一。 OGDHC是线粒体三羧酸循环中的关键限速酶也在谷氨酸代谢中起到重要作用。 在谷氨酸代谢过程中，谷氨酰胺在线粒体中被利用，在谷氨酰胺酶和谷氨酸脱氢酶的作用下，通过两步转化为α-酮戊二酸。 OGDHC可将α-酮戊二酸转化为琥珀酸，之后进一步转化为琥珀酰辅酶A …

Oxoglutarate dehydrogenase (OGDH) is the first and rate-limiting component of the multi-enzyme OGDH complex (OGDHC) whose malfunction is associated with neuro-degeneration. The essential role of this complex is in the degradation of glucose and glutamate and the OGDHL gene (one component of OGDHC) i …

Jul 7, 2023 · Oxoglutarate dehydrogenase-like (OGDHL) is considered to be the isoenzyme of oxyglutarate dehydrogenase (OGDH) in the OGDH complex, which degrades glucose and glutamate....

Aug 25, 2023 · We found that OGDHL acts as a tumor suppressor by inhibiting the proliferation, migration, and invasion of ccRCC cells. Mechanistic studies revealed that FTO inhibits OGDHL expression in ccRCC...

Feb 8, 2025 · OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer.

2-酮戊二酸脱氢酶样蛋白 (2-oxoglutarate dehydrogenase-like, OGDHL)是Krebs循环中的限速酶，在线粒体代谢中起着关键作用。 OGDHL的表达主要在人类的大脑，提示OGDHL参与了脑的发育和功能。 本研究报告了来自 8个无关家系的9名携带OGDHL 双等位基因变异 的个体，他们的神经发育表型包括：癫痫、听力损失、视力障碍、步态共济失调、小头畸形和 胼胝体发育不良。 从携带双等位基因OGDHL变异的个体中鉴定出的9个单核苷酸变异 (SNV)都是功能缺失 (Loss-of …

Nov 29, 2023 · Using an unbiased genotype-first approach, we screened large, multiethnic aggregated sequencing datasets worldwide for biallelic OGDHL variants. We used CRISPR/Cas9 to generate zebrafish knockouts of ogdhl, ogdh paralogs, and dhtkd1 to investigate functional relationships and impact during development.