Promotion of axon regeneration and protection on injured retinal ...
2023年6月20日 · After targeting the key gene, we verified the role of the candidate factor in RGC protection and promotion of axon regeneration in vivo with two RGC-injured animal models …
A small molecule M1 promotes optic nerve regeneration to restore ... - PNAS
2022年10月28日 · Here, we report the induction of sustained axon regeneration, neural activities in the superior colliculus (SC), and visual function recovery after optic nerve crush (ONC) by …
Optic Nerve Crush in Mice to Study Retinal Ganglion Cell
2020年3月20日 · Herein, we describe a step-by-step protocol to assay RGC survival and regeneration in mice following AAV2-mediated transduction and ONC injury including 1) …
Circular RNA-based therapy provides sustained and robust ...
2024年9月10日 · To further characterize enhancement of LNP-circNGF treatment in resistance of RGC axons to ONC, we tracked the signaling of RGC axons in a retrograde manner, by …
Clinically relevant small-molecule promotes nerve repair and visual ...
2022年10月1日 · On day 12 post-ONC, mice were injected intravitreally with anterogradely transported cholera toxin subunit B (CTB) conjugated with Alexa Fluor 555 (CTB-555) to trace …
NFATc4 Knockout Promotes Neuroprotection and Retinal …
2024年4月19日 · Using the optic nerve crush (ONC) model, widely employed to study optic neuropathies and central nervous system axon injury, we found that NFATc4 is specifically but …
Exploration of the strategies to enhance the regeneration of the …
2022年6月1日 · A conventional optic nerve crush model was used to explore the number of regenerated axons at increasing distances from the site of the optic nerve lesion in the ONC …
Interleukin-4 protects retinal ganglion cells and promotes axon ...
2024年4月22日 · The protective effect of recombinant IL-4 protein on somas of RGCs was assessed using RBPMS-specific immunofluorescent staining in mouse models with optic …
Optic nerve regeneration screen identifies multiple genes …
2021年3月2日 · Suppression of 40 genes using viral-driven short hairpin RNAs (shRNAs) promotes retinal ganglion cell (RGC) axon regeneration after optic nerve crush (ONC), and …
Knockdown of Porf-2 restores visual function after optic nerve …
2023年8月28日 · Our study provides in-vivo supporting evidence that Porf-2 is a key regulator of RGC survival and axon regeneration after ONC injury, with an implication of therapeutic effect …