2016年10月25日 · G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti-lipolytic effects in adipocytes. However, to data, a role for GPR81 in the tumor microenvironment has not been clearly defined. Here, GPR81 expression in breast cancer pati …

2020年2月19日 · GPR81 is a G-protein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role to promote tumor growth by tumor cell-derived lactate. Here we asked whether...

G蛋白偶联受体81 (GPR81)属于G蛋白偶联受体家族 (GPCR),是在脂肪和肌肉细胞中发现的乳酸受体,GPR81也称为羟基羧酸受体1 (HCAR1).随着对GPR81研究的深入,发现其与肿瘤的发生,发展密切相关.GPR81在不同类型的肿瘤组织中发挥不同的生物学作用,GPR81在肺癌,胰腺癌,胆管腺癌 ...

2025年1月7日 · Oncotin is used for first line therapy for lung cancer, head & neck cancer and for the treatment of advanced and metastatic ovarian carcinoma, bladder carcinoma and testis …

2021年1月1日 · Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression.

2015年10月1日 · Animal models investigating IL-31 physiology and recent findings for IL-31 in human disease. Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ).

Oncotin (cisplatin injection) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate …

G protein-coupled receptor 81 (GPR81) inhibition attenuated ischemic neuronal death. Lactate may aggravate ischemic brain injury by activating GPR81. GPR81 antagonism might be a novel therapeutic strategy for the treatment of cerebral ischemia.

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CD81 molecule, also known as CD81 (C luster of D ifferentiation 81), is a protein which in humans is encoded by the CD81 gene. [5][6] It is also known as 26 kDa cell surface protein, TAPA-1 (T arget of the A nti p roliferative A ntibody 1), and Tetraspanin-28 (Tspan-28).