2024年12月25日 · ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1) is a Protein Coding gene. Diseases associated with ORAI1 include Immunodeficiency 9 and Myopathy, Tubular Aggregate, 2. Among its related pathways are …

Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. [5] [6] [7] Orai channels play an important role in the activation of T-lymphocytes.

2006年8月20日 · We and others recently identified Drosophila Orai and human Orai1 (also called TMEM142A) as critical components of store-operated Ca2+ entry downstream of STIM6,7,8.

2025年2月8日 · ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling. Impact of SOCE Abolition by ORAI1 Knockout on the Proliferation, Adhesion, and Migration of HEK-293 Cells.

2020年5月15日 · We reveal that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of receptor-activated Ca2+ signals, reflecting their enhanced basal STIM1-binding and heightened...

STIM1 couples with Orai1 at the junctions by protein interaction and induces opening of CRAC channels (Phase II, store-operated Ca 2+ entry). Opening of Orai1 raises the intracellular Ca 2+ concentration and enhances mitochondrial Ca 2+ uptake.

Orai1, a pivotal actor of SOCE, was first identified by three independent interference RNA screens in Drosophila S2 cells that related a few Drosophila genes to SOCE, including olf186-F, named Drosophila Orai (dOrai1) [6,7,8].

2025年1月5日 · Title: Orai1 and Orai3 act through distinct signalling axes to promote stemness and tumorigenicity of breast cancer stem cells. Remodeling Ca[2+] dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

2025年2月8日 · Clinical resource with information about ORAI1, Combined immunodeficiency due to ORAI1 deficiency, Myopathy, tubular aggregate, 2, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

ORAI 钙释放激活钙调节因子 1： 由该基因编码的蛋白质是一种膜钙通道亚基，当钙储备耗尽时，它会被钙传感器 STIM1 激活。这种类型的通道是钙流入 T 细胞的主要途径。该基因的缺陷是由于 1 型钙进入缺陷 (IDTICED1) 导致的 T 细胞失活导致免疫功能障碍的原因。[RefSeq 提供，2011 …