腹外侧视前区（vlpo）是位于下丘脑前部的一个小神经元群。 [1] [2] 腹外侧视前区是控制人們唤醒与睡眠的神经系统。 [1] [2] 在非快速动眼睡眠期间，腹外侧视前核會释放抑制性神经递质。 [3]

2014年3月20日 · In one model of mouse sleep-wake behavior by Diniz Behn et al., Orx was modeled as a state-dependent modulation of the inhibition of the VLPO by wake-active neuronal populations using a saturating mathematical form that mimics Orx activation on a timescale of minutes or longer.

2022年7月18日 · Here we show using in vivo optogenetics, in vitro optogenetic-based circuit mapping, and single-cell transcriptomics that orexin neurons also contribute to arousal maintenance through indirect...

我们研究了外侧下丘脑（LHA）中的食欲蛋白（Orexin）神经元对睡眠-觉醒开关的稳定作用，以及缺失这些神经元后为何会导致昏睡病的发病机制。 我们还研究了基本动机对睡眠调控系统的影响，包括睡眠的稳态控制机制、形成睡眠-觉醒周期的昼夜节律调控机制和对外界环境变化作出相应适应的变构调控机制。 该神经元回路系统内发生的相互作用有望解释各种药物对睡眠和觉醒的影响机制。 1. 上行激活系统使我们从睡梦中醒来. von Economo昏睡性脑炎患者大部分都会表现出睡 …

2014年3月20日 · During sleep, both Orx and MA are inhibited by the VLPO, and the subsequent reduction in Orx input to the MA indirectly stabilizes sustained sleep episodes. Simulating a loss of Orx, the model produces dynamics resembling narcolepsy, including frequent transitions between states, reduced waking arousal levels, and a normal daily amount of total ...

2018年7月23日 · 下丘脑腹外侧视前核（VLPO）在持续睡眠（入睡-保持睡眠）中起关键作用，而下丘脑的侧后部位神经元对保持清醒有用，这些神经元包括LHA脑区的食欲素神经元和TMN脑区的组胺能神经。 睡眠是一个自主过程，并非总是在我们直接、自愿的控制之下。 醒着或睡着，我们通常归属于两个生物调节基本过程：睡眠稳定（sleep homeostasis），即睡眠压力（sleep pressure）；另一个过程被称为昼夜节律（circadian rhythm），更广泛的说法也叫生物 …

2014年3月20日 · During sleep, both Orx and MA are inhibited by the VLPO, and the subsequent reduction in Orx input to the MA indirectly stabilizes sustained sleep episodes. Simulating a loss of Orx, the model produces dynamics resembling narcolepsy, including frequent transitions between states, reduced waking arousal levels, and a normal daily amount of total ...

Orexin (ORX) neurons indirectly inhibit neurons of the ventrolateral preoptic nucleus (VLPO) of the hypothalamus, which promote sleep, express gamma-aminobutyric acid (GABA) and galanin, and inhibit ORX neurons.

During sleep, both Orx and MA are inhibited by the VLPO, and the subsequent reduction in Orx input to the MA indirectly stabilizes sustained sleep episodes. Simulating a loss of Orx, the model produces dynamics resembling

2020年6月10日 · 本文探讨了睡眠周期的数学模型，包括生物学层面的视交叉上核（scn）、食欲肽（orx）、睡眠促进核（vlpo）等相互作用。 通过Morris–Lecar和Hodgkin–Huxley模型，分析了睡眠与清醒状态的转换，以及REM和NREM睡眠阶段的交替。