抑瘤素M（Oncostatin-M，OSM）属于IL-6家族成员中的多效性细胞因子，在1986年首次从U937组织性淋巴瘤细胞中释放并分离出来，因其可抑制黑色素瘤细胞的增殖能力而得名。 OSM基因位于22q12染色体上，由3个外显子和2个内含子组成，位置邻近于LIF。 OSM蛋白全长含有239至263个氨基酸，折叠成一个与其他IL-6家族相似的四螺旋束长链蛋白（图1） [3]。 人源OSM多肽含252个氨基酸残基，N-末端是由25个氨基酸残基构成的信号肽，C-末端由32个氨基酸残基构成。

Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR), is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. [5] [6] OSMR is a member of the type I cytokine receptor family.

2021年12月17日 · Here, we describe how heterocellular Oncostatin M (OSM) - Oncostatin M Receptor (OSMR) signalling reprograms fibroblasts, regulates tumour growth and metastasis.

2024年9月12日 · Here, we investigated OSM-OSMRβ signaling in adult mouse hematopoietic stem cells (HSCs) using the conditional Osmrfl/fl mouse model B6;129- Osmrtm1.1Nat /J. We crossed Osmrfl/fl mice to...

2021年4月21日 · 抑瘤素M（OSM）是继白介素-6（interleukin-6，IL-6）、白血病抑制因子 （Ieukemia inhibitory factor, LIF）、肿瘤坏死因子（tumor necrosis factor, TNF）以及睫状神营养因子（ciliary neurotrophic factor, CNTF）等后发现的又一种具有重要生物学意义的细胞因子。 体外研究表明抑瘤素M的主要生物学功能是抑制多种肿瘤细胞的生长，并能诱导某些肿瘤细胞的分化 。 从发育生物学的角度来看，肿瘤是因细胞的正常分化受到了某种因素的影响而发生的。 无 …

2024年6月5日 · OSM is one of the IL6-family proteins, which binds to its receptor OSMR, and heterodimerizes with GP130 (a.k.a. IL6ST) or Interleukin-31 receptor (IL31RA) then activates downstream signaling...

2021年12月17日 · Here, we describe how heterocellular Oncostatin M (OSM) - Oncostatin M Receptor (OSMR) signalling reprograms fibroblasts, regulates tumour growth and metastasis. Macrophage-secreted OSM stimulates inflammatory gene expression in cancer-associated fibroblasts (CAFs), which in turn induce a pro-tumourigenic environment and engage tumour cell ...

2015年10月1日 · Animal models investigating IL-31 physiology and recent findings for IL-31 in human disease. Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ).

2024年12月25日 · OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include Amyloidosis, Primary Localized Cutaneous, 1 and Primary Cutaneous Amyloidosis . Among its related pathways are Akt Signaling and Interleukin-6 …

2022年6月28日 · Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of …