Dec 25, 2024 · OTX1 (Orthodenticle Homeobox 1) is a Protein Coding gene. Diseases associated with OTX1 include Autism Spectrum Disorder and Agnathia-Otocephaly Complex. Among its related pathways are Beta-2 adrenergic-dependent CFTR expression and Transcriptional Regulatory Network in Embryonic Stem Cell.

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene. [5][6] This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development.

Dec 1, 1998 · Findings from several groups now confirm the importance of Otx2 in the early specification of neuroectoderm destined to become fore–midbrain, the existence of an Otx gene dosage‐dependent mechanism in patterning the developing brain, and the …

OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma. OTX1 exerts an oncogenic role and is negatively regulated by miR129-5p in laryngeal squamous cell carcinoma. Long non-coding RNA HNF1A-AS1 upregulates OTX1 to enhance angiogenesis in colon cancer via the binding of transcription factor PBX3.

Jan 4, 2025 · Title: OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma. OTX1 exerts an oncogenic role and is negatively regulated by miR129-5p in laryngeal squamous cell carcinoma.

Silencing the OTX1 gene suppressed the proliferation, migration and invasion of NCI-H292 and XWLC cells, impeded the cell cycle transition from G2 to M phase, and accelerated apoptosis, revealing OTX1, a regulator of NSCLC, as a potential new therapeutic target.

Feb 9, 2018 · Otx1 knockdown by in utero electroporation in the mouse brain reduced the proportion of the G 1 phase while increasing the S and M phases of progenitor cells. The knockdown diminished Tbr1+ neurons but increased GFAP+ astrocytes in the early postnatal cortex as revealed by lineage tracing study.

通过免疫共沉淀耦联质谱技术我们发现OTX1 (Orthodenticle homeobox 1)为FOXC2的结合蛋白，且OTX1在结直肠癌中的表达异常升高。 进一步研究我们发现上调OTX1能够诱导结直肠癌细胞发生EMT，并促进结肠癌的侵袭及远处转移。

OTX1 (orthodenticle homeobox 1) is an important transcription factor involved in various diseases, such as cancers. The aim of this study was to further investigate the role of OTX1 in BC. In this study, differentially expressed genes (DEGs) were screened from tumor tissues and para-cancerous tissues by bioinformatics.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.