Otx2 is a group of homeobox genes that are typically described as a head organizer in the primitive streak stage of embryonic development. Otx2, which is an encoded protein that plays …

2024年12月25日 · OTX2 (Orthodenticle Homeobox 2) is a Protein Coding gene. Diseases associated with OTX2 include Microphthalmia, Syndromic 5 and Pituitary Hormone Deficiency, …

2014年6月26日 · The transcription factor Otx2 plays an important role in neural development and in the exit of embryonic stem cells from the pluripotent ground state. In this study, Yang et al. …

2013年6月1日 · The Otx2 homeobox gene is one of the most important genes for forebrain induction and head formation in vertebrates. In mouse embryo, Otx2 is already transcribed …

The OTX2 gene provides instructions for producing a protein that regulates the activity of other genes. On the basis of this action, the OTX2 protein is called a transcription factor. The OTX2 …

2023年2月27日 · Here, we discover an unconventional nuclear export of the TF, orthodenticle homeobox 2 (OTX2), in nuclear budding vesicles, which transport OTX2 to the lysosome. We …

2021年5月7日 · Here, we investigated the consequences of reduced OTX2 levels in Otx2 heterozygote mice, as well as in Otx2+/AA and scFvOtx2tg/0 mouse models for decreasing …

The Otx2 gene encodes a transcription factor essential for the normal development of brain, cerebellum, pineal gland, and eye. In the retina, Otx2 has essential functions from early …

OTX2 mutation is a cause of combined pituitary hormone deficiency (CPHD). OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium. A …

该基因的突变会导致综合征性小眼症 5 (MCOPS5) 和垂体激素联合缺乏症 6 (CPHD6) 。 该基因也被怀疑在髓母细胞瘤中具有致癌作用。 可变剪接导致编码不同异构体的多个转录变体。 已知 …