OTX2 signaling in retinal dysfunction, degeneration and …
OTX2 expression in RPE is necessary for photoreceptor survival. When OTX2 is specifically knocked out in mature retina including the RPE, photoreceptors degenerate and mice have a …
A distal enhancer that directs Otx2 expression in the retinal …
Homeodomain transcription factor Otx2 is essential for embryonic development of multiple head tissues, including retinal pigment epithelium (RPE) and neuroretina. Temporospatial regulation …
Downregulation of Otx2 in the dedifferentiated RPE cells of ...
2005年3月22日 · To understand the role of Otx2 during transdifferentiation of RPE cells, we cloned a Cynops Otx2 cDNA, and explored its expression by RT-PCR, immunohistochemistry …
Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue ...
2018年1月3日 · Our results are consistent with the role of Otx2 in the adult mouse RPE, because the conditional knockout of Otx2 leads to disruption of photoreceptor-RPE adhesion and …
Loss of Otx2 in the Adult Retina Disrupts Retinal Pigment …
We use chromatin immunoprecipitation followed by massive sequencing (ChIP-seq) analysis to identify the molecular network controlled in vivo by Otx2 in RPE cells. We uncover four RPE …
The LHX2-OTX2 transcriptional regulatory module controls retinal …
2023年1月17日 · By combining mechanistic findings in stem-cell-derived human RPE, in vivo functional studies in mice and global transcriptomic and proteomic analyses, we revealed that …
OTX2 Activates the Molecular Network Underlying Retina Pigment ...
This study provides molecular evidence that OTX2 regulates the differentiation of the RPE. First, OTX2 is able to induce a pigmented phenotype in transfected retina cells. Second, OTX2 …
A Stage-Specific OTX2 Regulatory Network and Maturation …
We identify a number of functional pathways that could potentially act to solidify the RPE fate, and we present evidence that OTX2 has the potential to act as a primary determinant in restricting …
The LHX2-OTX2 transcriptional regulatory module controls retinal ...
2023年1月17日 · By combining mechanistic findings in stem-cell-derived human RPE, in vivo functional studies in mice and global transcriptomic and proteomic analyses, we revealed that …
Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE …
2010年7月21日 · To investigate morphological consequences of Otx2 knockout, both on RPE cells and on photoreceptor outer segments, we performed electron microscopic analysis of …