骨密度（bmd）测量、显微ct分析和组织形态计量学分析用于评估ovx小鼠 [2,3] 。手术后采集骨骼并进行测试。百奥赛图在c57bl/6小鼠中建立了稳定的ovx诱导的骨质疏松症模型方案，可用于骨质疏松症的临床前研究和药效学评价。

The aim of this study is to provide a 4-step guideline for inducing a rat model of osteoporosis by ovariectomy (OVX): (1) selection of the rat strain, (2) choosing the appropriate age of rats at the time of OVX, (3) selection of an appropriate surgical method and verification of OVX, and (4) evaluation of OVX-induced osteoporosis.

2019年11月23日 · Results: Bone mineral density (BMD), bone volume fraction (BV/TV), Trabecular Number (Tb.N), and Trabecular Thickness (Tb.Th) decreased, while Trabecular Spacing (Tb.Sp) and Structure Model Index (SMI) increased overtime in all the three groups. In OVX-oxytocin group, the bone deterioration tendency is slowing down compared with that of …

2021年6月1日 · In this study, we compared the repair process between metaphysis and diaphysis of ovariectomized (OVX) and Sham mice, and analyzed the effects of short-term estrogen administration in OVX mice. Mice were divided into four experimental groups, including Sham, OVX, OVX + vehicle, and OVX + 17β-estradiol (E2).

The purpose of this study was to use a high-resolution micro-computed tomography (micro-CT) and dual energy X-ray absorptionmeter (DEXA) to investigate the changes in micro-architecture and bone mineral density (BMD) in a sheep model resulted from ovariectomy (OVX). Biomechanical tests were performed to evaluate the strength of the trabecular bone.

2011年9月17日 · This study evaluates the effect of hydrolyzed collagen (HC) on bone health of ovariectomized mice (OVX) at different ages. Twenty-six weeks after the OVX procedure, HC ingestion was still able to improve significantly bone mineral density (BMD) and some femur biomechanical parameters.

在ovx手术后的第0、4、8、10和12周，分别测量了三组的骨矿物质密度（bmd）和骨微结构参数。 骨矿物质密度（BMD），骨体积分数（BV / TV），骨小梁数（Tb.N）和骨小梁厚度（Tb.Th）降低，而骨小梁间距（Tb.Sp）和结构模型指数（SMI）增加这三组都加班。

The OVX rat caudal spine exhibits pathologic bone changes consistent with the osteoporosis phenotype, including decreased BMD, diminished trabecular network density, cortical thinning, and decreased mechanical strength.

Bone mineral density (BMD) measurement, micro-CT analysis and histomorphometric analysis were used to evaluate the OVX mice [2, 3]. Bones were harvested and tested after the operation. A stable OVX-induced osteoporosis disease model protocol was established in C57BL/6 mice by Biocytogen, which can be used for preclinical studies and ...

2011年1月1日 · In other studies, OVX rats and mice are used to show how certain compounds have protective effects against ovariectomy-induced bone loss: a phosphodiesterase 4 inhibitor, XT-44, increased BMD of OVX rats.119 Transplantation of mesenchymal stem cells over expressing RANK-Fc and CXC chemokine receptor-4 …