2017年9月14日 · Specifically, 12 week-old C57BL/6J mice underwent OVX/SHM surgery; 9 weeks after we inserted special metal-ceramics implants into the 6 th caudal vertebra and we measured bone response with in vivo micro-CT weekly for the following 6 weeks. Our results indicated that ovariectomized mice showed a reduced ability to increase the thickness of the ...

2015年6月1日 · OVX caused a marked deterioration of the trabecular and cortical bone micro-structure, manifested as a considerable decrease in Ct.Th (−9%), BV (−52.6%), BV/TV (−63.6%), Tb.N (−75.0%) and ...

Here, we show that ovariectomy (ovx) expanded intestinal Th17 cells and TNF + T cells, increased their S1P receptor 1–mediated (S1PR1-mediated) egress from the intestine, and enhanced their subsequent influx into the BM through CXCR3- …

小鼠卵巢摘除（ovariectomy，简称ovx）是一个较成熟的动物模型，通过双侧 卵巢摘除术 可以成功建立模拟雌激素缺乏而导致的骨质疏松动物模型。 卵巢所在位置 图源网络

2020年6月1日 · Recombinant parathyroid hormone [1–34] (PTH (1–34)) is the basis of two FDA-approved bone anabolics prescribed for treatment of OP and associated bone...

2024年7月30日 · Micro-CT and HE staining analyses revealed that ABX intervention could effectively mitigate bone loss and restore bone microstructure in OVX rats (Fig. 7 A-E), which were confirmed following quantitative analysis, indicating increased BMD, Tb.Th, BV/TV, and Tb.N, along with decreased Tb.Pf in the proximal femur of rats in the ABX group.

Micro-CT 检测示，与假手术组相比，OVX组Tb.Th、Tb.N和BV/TV降低，而Tb.Sp增高（P <0.05）；经Rspo2干预后，除Tb.Th外OVX+Rspo2组上述指标均得到改善（P <0.05）。 Rspo2能够促进BMSCs向成骨细胞分化，改善小鼠由于雌激素缺乏导致的骨质疏松，促进骨形成。 Keywords: 脊椎蛋白2, BMSCs, 骨质疏松, 骨形成, 小鼠.

2011年6月1日 · 3-month-old female C57BL/6 mice were randomly divided into an ovariectomy group (OVX) and a sham-operated group (Sham). At 6 weeks post-surgery, 7 mice from each group were sacrificed to examine the distal femur and femoral shaft by both micro-CT and mechanical testing for confirming established osteoporosis induced by OVX.

本研究以C57小鼠为实验动物，通过双侧卵巢摘除术诱导骨质疏松模型，模拟绝经后不同时期，应用micro-CT扫描和骨组织切片染色技术，观察术后不同时间点的骨量和骨组织形态学变化，旨在发现小鼠绝经后骨质动态变化规律，为骨质疏松疾病模型观察提供参考，也可以为筛选疾病防治的最佳阶段提供依据。 7周龄未孕雌性C57小鼠 (SPF级)，购自重庆医科大学实验动物中心，分笼后继续于该中心在标准条件下饲养...

2023年2月20日 · This study found that CA prevented estrogen-deficiency-induced bone loss and suppressed osteoclastogenesis in ovariectomized (OVX) mice by inhibiting intracellular reactive oxygen species (ROS) levels.