3-oxoacid CoA-transferase 1 (OXCT1) is an enzyme that in humans is encoded by the OXCT1 gene. [5] [6] It is also known as succinyl-CoA-3-oxaloacid CoA transferase (SCOT). Mutations in the OXCT1 gene are associated with succinyl-CoA:3-oxoacid CoA transferase deficiency. [7] This gene encodes a member of the 3-oxoacid CoA-transferase gene family.

2024年1月3日，中国科学技术大学张华凤及广东省人民医院高平共同通讯在 Molecular Cell 在线发表题为“ OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB ”的研究论文， 该研究发现OXCT1作为琥珀酰转移酶，通过琥珀酰化LACTB导致肝 ...

2024年12月25日 · OXCT1 (3-Oxoacid CoA-Transferase 1) is a Protein Coding gene. Diseases associated with OXCT1 include Succinyl-Coa:3-Oxoacid-Coa Transferase Deficiency and Disorder Of Keton Body Transport. Among its related …

1 月 3 日本团队发表了新的研究进展，发现 OXCT1 是一种新型的琥珀酰基转移酶，调控抑癌蛋白酶 LACTB 等的琥珀酰化，从而促进肝癌， 相关成果以题为 OXCT1 functions as a succinyltransferase contributing to hepatocellular carcinoma via succinylating LACTB 发表在国际知名期刊 《 Molecular ...

2025年2月20日 · Here, we demonstrate that 3-oxoacid CoA-transferase 1 (OXCT1), a rate-limiting enzyme in ketolysis, interacts with SUCLA2 upon IGF1 stimulation in HCC cells. This interaction results from ERK2-mediated SUCLA2 S124 phosphorylation and subsequent PIN1-mediated cis-trans isomerization of SUCLA2.

2024年2月1日 · Here, we show that OXCT1, an enzyme catalyzing ketone body oxidation, functions as a lysine succinyltransferase to contribute to tumor progression. Mechanistically, we find that OXCT1 functions as a succinyltransferase, with residue G424 essential for this activity.

2025年2月20日 · Here, we demonstrate that 3-oxoacid CoA-transferase 1 (OXCT1), a rate-limiting enzyme in ketolysis, interacts with SUCLA2 upon IGF1 stimulation in HCC cells. This interaction results from ERK2-mediated SUCLA2 S124 phosphorylation and subsequent PIN1-mediated cis-trans isomerization of SUCLA2.

2024年10月1日 · Targeting macrophage metabolism to counteract immune suppression presents a promising avenue for hepatocellular carcinoma treatment. Herein, we found that the ketogenesis gene OXCT1 was highly expressed in tumor-associated macrophages (TAMs) and promoted tumor growth by reprogramming TAMs toward a protumor phenotype. Pharmacological targeting ...

2024年12月16日 · 该研究探讨了3-氧酸辅酶A转移酶1（OXCT1）在肝细胞癌（HCC）中的免疫调节作用，特别是其在肿瘤相关巨噬细胞（TAMs）中的作用，以及如何通过调节CD8+ T细胞的抗肿瘤免疫反应来影响HCC的进展。 文章的主要发现和结论如下： OXCT1在HCC中的作用：研究发现，OXCT1在HCC细胞中高表达，并通过促进肿瘤进展来激活酮解作用。 此外，OXCT1在TAMs中的表达也增加，且与患者的预后不良相关。 伊莱博生物已建立完善的生物信息学分析与靶点 …

编码的蛋白质是一种同型二聚体线粒体基质酶，通过催化辅酶 A 从琥珀酰辅酶 A 到乙酰乙酸的可逆转移，在肝外酮体分解代谢中发挥核心作用。 该基因的突变与琥珀酰辅酶 A:3-含氧酸辅酶 A 转移酶缺乏症有关。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the 3-oxoacid CoA-transferase gene family.