p53（肿瘤抑制因子）和p38（MAPK）：两种经典信号通路 - 知乎
p53 和 p38 ：两种经典信号通路. 前言. p53是一种肿瘤抑制因子，在维持基因组稳定和限制细胞异常增殖方面具有重要功能。p38对一些转录因子具有磷酸化和激活的作用，包括p53。二者相 …
The role of p38 MAPK pathway in p53 compromised state and
This review focuses on activation of p38 in response to genotoxic stress induced DNA damage in p53 mutated or compromised state and its possible cross talk with telomere shelterin proteins. …
The p38 Pathway: From Biology to Cancer Therapy - PMC
Additionally, p38 regulates p53 activation either directly or indirectly through HBP1 . p53 acts as a tumor suppressor by controlling the G1/S checkpoint, and its activation results in the …
关于肿瘤克星——P53，这些你都知道吗？ - 知乎专栏
在p53-null肿瘤中，提供p53蛋白、mRNA和DNA可以恢复p53表达并消灭肿瘤细胞。 总之，P53 蛋白是一种转录因子和肿瘤抑制蛋白，可结合 DNA 并调控多种转录靶标，响应细胞应激或 DNA …
热门靶点p38 MAPK - 知乎 - 知乎专栏
目前认为p38 MAPK促进细胞凋亡的机制是通过磷酸化P53、诱导Bax转位、增强c-myc的表达、参与Fas/FasI介导的凋亡、增强TNF-d表达、激活c-jun和c-fos等多种途径, 诱导细胞凋亡的[1]。
The role of p38 MAPK pathway in p53 compromised state and …
2018年12月1日 · p38 MAPK signaling pathway in mutated or compromised function of p53. In cancer cells where p53 is mutated, p38 may perform the function of p53 either partially or fully …
肿瘤基础科研之万能钥匙——p53蛋白简介及通路关系分析 纽普生物
p53 基因属于抑癌基因，位于染色体17p13.1，基因全长16~20kb，含11个外显子，并且2~11外显子编码分子量为53kD的p53蛋白分子。 P53作为转录因子能够调节各种各样基因的表达，其中 …
Human papillomavirus type 38 alters wild-type p53 activity to …
In the beta human papillomavirus type 38 (HPV38) experimental model, the viral proteins E6 and E7 promote accumulation of a wild-type (WT) p53 form in human keratinocytes (HKs), …
Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …
Tumor suppressor p53: Biology, signaling pathways, and ... - PubMed
The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads have …