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Cell Signaling Technology (CST)
https://www.cellsignal.cn › products › primary-antibodies
Phospho-SMAD2 (Ser465/467)/SMAD3 (Ser423/425) …
This antibody recognizes phosphorylated SMAD2 and SMAD3 proteins, which are involved in TGF-β signaling pathway. It can be used for western blotting and has specificity for human, mouse, rat and monkey samples.
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researchgate.net
Enhanced p-Smad2 signaling in the alveolar epithelial cells (AECs) of... | Download Scientific ...
researchgate.net
Experimental and modeling analysis of P-Smad2 response to very short... | Download Scientific ...
frontiersin.org
Frontiers | The Role of SMAD2/3 in Human Embryonic Stem Cells
researchgate.net
The expression changes of Smad2, p-Smad2, Smad3, p-Smad3 and Smad7... | Download Scientific Diagram
researchgate.net
Analysis of Smad4 and P-Smad2/3 protein expression in different... | Download Scientific Diagram
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Cell Signaling Technology
https://www.cellsignal.com › products › primary-antibodies
Phospho-SMAD2 (Ser465/467) (138D4) Rabbit mAb …
Phospho-SMAD2 (Ser465/467) (138D4) Rabbit mAb detects endogenous levels of SMAD2 only when dually phosphorylated at serines 465 and 467, and may detect SMAD3 phosphorylated at the equivalent sites. This antibody does not …
Thermo Fisher Scientific
https://www.thermofisher.com › antibody › product
Phospho-SMAD2 (Ser465, Ser467) Polyclonal Antibody
The changes in the expression of Smad2 and phosphorylated Smad2 (P-Smad2) proteins (relative to beta-actin) were determined by Western blot analysis. The percentage change is …
P-Smad2 的研究
PubMed
High p-Smad2 expression in stromal fibroblasts predicts poor survival in patients with clinical stage I to IIIA non-small cell lung cancer
Background: Increasing evidence indicates that the TGFβ/Smad signaling pathway plays a prominent role in tumor initiation, progression, and metastasis. Therefore, we investigate the expression of p-Smad2 in surgical resection specimens from non-small cell lung cancer, and evaluate the prognostic sig...
作者: Yongbing Chen
已发布: 2014/11/05
Keywords: Increasing …
ScienceDirect
Review Phosphatases in SMAD regulation
SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling....
已发布: 2012/07/04
Cited By: 0
Keywords: SMAD pho…
PubMed
Expression pattern of p-Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma
The present study examined SMAD family member 4 (Smad4), SMAD family member 2 (Smad2) and phosphorylated (p-)Smad2 expression in biopsy specimens from patients with invasive breast ductal carcinoma, in order to assess their abilities as prognostic markers. A total of 126 tissue samples were selected...
作者: Nannan Liu
已发布: 2020/3
Keywords: SMAD fami…
Abcam
https://www.abcam.com › en-us › products › primary-antibodies
Anti-Smad2 (phospho S467) antibody (ab53100) - Abcam
Rabbit Polyclonal SMAD2 phospho S467 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 97 publications. Immunogen corresponding to Synthetic Peptide …
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Abcam中文官网
https://www.abcam.cn › products › primary-antibodies
Anti-Smad2 (phospho S467)抗体(ab53100) - Abcam中 …
Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates …
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类别: Smads
百度知道
https://zhidao.baidu.com › question
smad2和p-smad2的区别 - 百度知道
p-smad2是磷酸化的smad2。 Smad2/3 的磷酸化激活是Smad 信号通路激活的最重要一步及标志，P-Smad2/3 表达程度即意味着Smad 信号转导通路激活的程度
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What is the difference between SMAD2 and SMAD3?
At the biochemistry level, several lines of evidence demonstrate obvious differences between Smad2 and Smad3. In the basal state, Smad2 is found mostly as monomer, whereas Smad3 exists in multiple oligomeric states 21. Smad3, but not Smad2, binds DNA through the β-hairpin DNA-interaction motif within the MH1 region 22, 23, 24.
Smad2 and Smad3 have differential sensitivity in relaying TGFβ
nature.com
What is the difference between endogenous SMAD2 and SMAD3?
Endogenous Smad2 and Smad3 also showed distinct subcellular distribution. As shown in Fig. 1b–g, in the absence of TGFβ activation, endogenous Smad2 was mainly detected in the cytoplasm, while a large number of Smad3 was enriched within the nucleus in human ESCs, HEK 293 cells and human skin fibroblast cells.
Smad2 and Smad3 have differential sensitivity in relaying TGFβ
nature.com
Which motifs are enriched in Smad2 and SMAD3 binding areas?
The aligned motifs enriched in both Smad2 and Smad3 binding areas mostly have the 5′–AGAC-3′ core sequences, identified as Smad-binding element (SBE) in both in vitro and in vivo studies for interaction with the MH1 domain of Smads 22 (Fig. 7c). Smad2 and Smad3 share similar DNA binding motifs but show different transcriptional activities.
Smad2 and Smad3 have differential sensitivity in relaying TGFβ
nature.com
Does knockout of Smad2 increase E-cadherin?
RT-PCR analysis also showed that knockout of Smad2 greatly elevated E-Cadherin, while block N-Cadherin expression (Fig. 5g,h). The Switch from E-Cadherin to N-Cadherin has been recognized as a pivotal hallmark of epithelial to mesenchymal transition (EMT), which can also be triggered by TGFβ activation.
Smad2 and Smad3 have differential sensitivity in relaying TGFβ
nature.com
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艾比玛特 Abmart
https://www.ab-mart.com.cn › page.aspx
Phospho-Smad2 (Ser465 + Ser467) Antibody_经典一抗-
KLH conjugated Synthesised phosphopeptide derived from human SMAD2 around the phosphorylation site of Ser465/467
Biocompare
https://www.biocompare.com
Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb from Cell …
Antibodies against histone H3 (#9715), p‐Smad3 (#9520), Smad3 (#9523), p‐Smad2 (#3108), Smad2 (#5339) and COL1A1 (#72026) were purchased from Cell Signaling Technology Inc. …
Nature
https://www.nature.com › articles
Smad2 and Smad3 have differential sensitivity in relaying TGFβ ...
2016年2月24日 · Smad2-, Smad3-bound peaks were identified by macs14 (version 1.4.2) with a P-value cutoff of 10–4 by using GFP as control and removal input background. Peak enriched …
PubMed
https://pubmed.ncbi.nlm.nih.gov
High p-Smad2 expression in stromal fibroblasts predicts poor …
2014年11月5日 · Therefore, we investigate the expression of p-Smad2 in surgical resection specimens from non-small cell lung cancer, and evaluate the prognostic significance of p …
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