Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers , specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.

2024年12月25日 · PTEN (Phosphatase And Tensin Homolog) is a Protein Coding gene. Diseases associated with PTEN include Cowden Syndrome 1 and Macrocephaly/Autism Syndrome . Among its related pathways are Prolactin Signaling and PIP3 activates AKT signaling .

PHTS is caused by alterations, also known as “mutations," of the PTEN gene on chromosome 10. In some cases, all or part of the gene is deleted. The condition can be inherited or caused by “new” mutations in one of the father’s sperm, mother’s eggs, or in a cell of the developing fetus.

More than 30 mutations in the gene have been found to cause Bannayan-Riley-Ruvalcaba syndrome. Common features of this condition include a large head size (macrocephaly), multiple noncancerous tumors and tumor-like growths called hamartomas, and …

PTEN Hamartoma Tumor syndrome (PHTS) is a rare genetic condition that causes an increased risk for certain cancers, benign growths, and neurodevelopmental disorders. PHTS describes any person who is found to have a change, or mutation, in the PTEN gene; some persons may also carry diagnoses of Cowden syndrome or Bannayan-Riley-Ruvalcaba ...

The PTEN genetic test is used to look for changes in your PTEN gene. It's not a routine test. It may be used to: Find out if a change in your PTEN gene is involved in cancer; Check for inherited changes in your PTEN gene if you have: Family members who have PTEN gene changes; Symptoms of PTEN hamartoma tumor syndrome (PHTS)

2023年7月17日 · Your PTEN gene normally helps prevent cancers. A mutation in this gene causes it to stop working like it should. It is important to understand that having a mutation in this gene does not mean you will definitely develop cancer. It means that you have an increased risk of developing certain types of cancers.

2025年1月14日 · The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is a critical tumor suppressor that plays an essential role in the development and functionality of the central nervous system. Located on chromosome 10 in humans and chromosome 19 in mice, PTEN encodes a protein that regulates …

2023年12月20日 · The Pten gene is a tumor suppressor gene that plays a critical role in the inhibition of cancer cell growth and tumor development. It encodes a protein called phosphatase and tensin homolog (PTEN), which acts as a negative regulator of …

The PTEN gene provides instructions for making an enzyme that is found in almost all tissues in the body. The enzyme acts as a tumor suppressor, which means that it helps regulate cell division by keeping cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way.