S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein [5] that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. [6][7] S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs.

2013年9月4日 · Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in...

Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here we review data implicating p11 in both the amplification of serotonergic signaling and the regulation of gene transcription.

2007年2月1日 · p11 (S100A10) is a member of the S100 protein family and forms a heterotetrameric complex with annexin 2. p11 has also been found to interact with a diverse set of proteins that includes several ion channels and the serotonin 5-HT 1B receptor.

2022年8月15日 · S100A10 (p11) is an emerging player in the neurobiology of depression and antidepressant actions. p11 was initially thought to be a modulator of serotonin receptor (5-HTR) trafficking and serotonergic transmission, though newly identified binding partners of p11 and neurobiological studies of these proteins have shed light on multifunctional ...

2010年10月20日 · In this issue of Science Translational Medicine, Alexander and colleagues describe coherent evidence drawn from humans and from modeled animals that supports a brain region–specific gene therapy for depression: adeno-associated virus (AAV)–mediated transfer of the gene encoding p11 to the nucleus accumbens (NAcc). The investigators found ...

2020年7月1日 · p11 (S100A10, annexin II light chain, calpactin I light chain) is a multifunctional protein that forms a heterotetrameric complex with Annexin A2, particularly at cell membranes. p11, alone or together with Annexin A2, interacts with several ion channels and receptors and regulates their cellular localization and function.

To better understand the involvement of p11 action in depressive-like states and to inform possible p11-based antidepressant therapies, we have used viral vector–mediated gene transfer to focally alter p11 expression in normal adult mouse brain.

2022年9月28日 · In this search for potential genetic predisposition to depressive disorders, the p11 protein caught the attention of scientists. It is encoded by the S100A10 gene.

2010年10月20日 · In this issue of Science Translational Medicine, Alexander and colleagues describe coherent evidence drawn from humans and from modeled animals that supports a brain region-specific gene therapy for depression: adeno-associated virus (AAV)-mediated transfer of the gene encoding p11 to the nucleus ac …