2013年2月1日 · Using a rational approach, we designed a novel and selective peptide inhibitor, P110, of excessive mitochondrial fission. P110 inhibits Drp1 enzyme activity and blocks Drp1/Fis1 interaction in vitro and in cultured neurons, whereas it has no effect on the interaction between Drp1 and other mitochondrial adaptors, as demonstrated by co ...

2023年7月19日 · Our study demonstrates that small molecule inhibitors of protein-protein interactions can be generated for Drp1 and that the P110 -binding site is an unrecognized allosteric backdoor for Drp1...

2025年1月17日 · 通过P110抑制Drp1/Fis1相互作用，有效降低了脓毒症小鼠线粒体细胞色素C的释放水平，并减轻了神经炎症，表现为肿瘤坏死因子TNFα、白介素ILI-β和白介素IL-6等炎症标志物的水平下降（见图4 d-f）。

2025年3月5日 · Here, we investigate the therapeutic potential of P110, a selective inhibitor of Drp1-mediated mitochondrial fission, in experimental models of DN. We demonstrate that P110 effectively reduces mitochondrial fragmentation and restores metabolic balance in renal tubular cells from DN patients.

2016年9月13日 · This study demonstrates that inhibition of Drp1 hyper-activation by a Drp1 peptide inhibitor P110 mitigates MPTP-induced loss of dopaminergic neurons, inhibits MPTP-induced reduction in...

P110 heptapeptide, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1.

P110是一种 Drp1-Fis1 相互作用的肽抑制剂，可减少多种神经退行性变、缺血和脓毒症模型的病理，而不会阻断 Drp1 的生理功能。 由于肽具有药代动力学限制，我们开始寻找能够模仿P110功效的小分子。

2017年6月1日 · Inhibition of Drp1 hyper-activation by the selective inhibitor P110 abolishes Drp1 translocation to the mitochondria, reduces mitochondrial fragmentation and stems necrosis in primary OLs exposed to TNF-α and H 2 O 2. Notably, in both types of mouse models, treatment with P110 significantly reduces the loss of mature OLs and demyelination ...

Here, we investigate the therapeutic potential of P110, a selective inhibitor of Drp1-mediated mitochondrial fission, in experimental models of DN. We demonstrate that P110 effectively reduces mitochondrial fragmentation and restores metabolic balance in …

2024年3月4日 · The use of the Drp1 inhibitor P110 significantly improved kidney function and structural damage. P110 reduced Drp1 mitochondrial translocation, disrupted the interaction between Drp1 and Fis1, without affecting the binding of Drp1 to other mitochondrial receptors such as MFF and Mid51.