p14ARF (also called ARF tumor suppressor, ARF, p14 ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). [1] p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). [2]

2024年12月24日 · CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) is a Protein Coding gene. Diseases associated with CDKN2A include Melanoma, Cutaneous Malignant 2 and Melanoma-Pancreatic Cancer Syndrome.

2024年11月11日 · p14 ARF reduces nucleolar NPM1 mobility and cell proliferation. NPM1 localizes p14 ARF in nucleoli to inhibit it from engaging other binding partners and activating anti-proliferative pathways...

P14 ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14 ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis. P14 ARF functions can be …

2023年1月18日 · Inactivation of the P16INK4A / P14ARF gene through hypermethylation, mutation, or deletion occurs in 100% of human PC [1, 2, 3, 4]. These three genetic mutations (K-Ras, p53, p14/p16) could be exploited in such a way that they become an “Achilles Heel”.

P14ARF is involved in cell cycle regulation by binding to HDM2, which in turn inhibits p53 degradation and leads to cell cycle arrest. HDM2 not only targets p53 for degradation, but also leads to functional inactivation of pRb.

p14ARF基因（p14ARF gene）是2017年全国科学技术名词审定委员会公布的老年医学名词，出自《老年医学名词》第一版。 肿瘤抑制基因，编码的蛋白能稳定和提高细胞p53水平，具有显著的细胞周期负调控和促进细胞衰老的作用。 定位于染色体9p21,编码两个不同的蛋白质,一个为p16INK4a，另一个为p14INK4a。 [1] 《老年医学名词》第一版. p14ARF基因（p14ARF gene）是2017年全国科学技术名词审定委员会公布的老年医学名词，出自《老年医学名词》第一版。

2006年11月21日 · CDKN2A locus on chromosome 9p21 encodes two tumour suppressor proteins pl6 INK4A, which is a regulator of the retinoblastoma (RB) protein, and p14 ARF, which is involved in the ARF–Mdm2–p53...

The CDKN2A gene encodes two different proteins with distinct functions: p16 and p14. The sequence codifying these two protein isoforms differs within the first exon (exon 1α and exon 1β for p16 and for p14, respectively) as a result of alternative splicing and a different reading frame ( Stone et al., 1995 ).

2017年5月8日 · p14 ARF, a tumor suppressor protein, encoded by the p16 tumor suppressor gene, has been reported to be associated with the clinicopathological features of lung cancer. However, the evaluated outcomes were inconsistent and remained inconclusive.