p16 is an inhibitor of cyclin-dependent kinases (CDK). It slows down the cell cycle by prohibiting progression from G1 phase to S phase. Otherwise, CDK4/6 binds cyclin D and forms an active protein complex that phosphorylates retinoblastoma protein (pRB).

p16ink4a (p16)是一种周期蛋白依赖的激酶抑制剂，通过抑制cdk4/6来阻断e2f转录因子的激活，负调控正常细胞的增殖。 INK4周期素依赖性激酶抑制剂家族成员包括 p16 INK4A、p15 INK4B、p18 INK4C 和 p19 INK4D。

【摘要】 抑癌基因 p16ink4a在特异地抑制 CDK4及CDK6在控制细胞生长、 抑制肿瘤发生、 促进细胞衰老等方面发挥关键生物学作用, 该基因失活后造成了细胞周期调控失常,使得细胞异常增殖,造成了肿瘤发生、 发展, 本文就近几年来相关它在染色体上定位、 结构以及在细胞增殖、 癌变过程中研究进展作一综述。 p16ink4a基因最早作为肿瘤抑制基因由美国冷泉试验室在1994年发觉, 属于细胞周期依靠性激酶抑制基因 INK4家族 一员 [1], 在正常细胞中含有调控细胞周期作用, 负调整 …

2012年10月1日 · Here, we investigated the compartment-specific role of cell cycle arrest and senescence in breast cancer tumor growth. For this purpose, we generated a number of hTERT-immortalized senescent fibroblast cell lines overexpressing CDK inhibitors, such as p16 (INK4A), p19 (ARF) or p21 (WAF1/CIP1).

2025年1月17日 · CDK activity is controlled through phosphorylation and inhibition by CDK inhibitors, such as p16. Mutations in p16 can lead to diseases such as cancer. This study examines a series of p16 mutants and their molecular interactions with CDK4 using modelling, molecular dynamics simulations, and docking studies.

2023年8月8日 · p16信号通路与细胞增殖和细胞周期调控相关的重要信号通路。p16属于Cyclin依赖性激酶抑制因子（CDKI）家族中的一员，它在细胞周期进程中充当抑制剂的角色。以下是p16信号通路的主要作用机制：

2017年12月12日 · The p16 Ink4a and p21 Waf1/Cip1 genes, which encode cyclin-dependent kinase (CDK) inhibitors, are upregulated in cultured mammalian primary cells upon detection of various potentially...

2021年6月7日 · To determine if CDK binding proteins could still access the tethered CDKs, we co-transfected a plasmid encoding mRuby3-tagged p16, an INK4 family member, which binds CDK6 with high affinity to...

As expected, induction of p16 (INK4a) results in a G1 cell cycle arrest by inhibiting phosphorylation of the retinoblastoma protein (pRb) by the cyclin-dependent kinases CDK4 and CDK6. However, induction of p16 (INK4a) also causes marked inhibition of CDK2 activity.

The p16 tumor suppressor gene encodes a specific inhibitor of cyclin-dependent kinase (CDK) 4 and 6 and is found altered in a wide range of human cancers. p16 plays a pivotal role in tumor suppressor networks through inducing cellular senescence that acts as a barrier to cellular transformation by o …