p16 (also known as p16 INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a …

2024年10月4日 · Currently, p16 Ink4a is one of the widely used markers for studying cellular senescence, and it plays a prominent role in inhibiting CDK4/6 and restricting the progression of G1 to S phase in the cell cycle. 16, 17 Numerous studies have utilized the activation of the p16 Ink4a promoter to identify cellular senescence in vivo and have thus ...

研究团队首先构建了一种荧光报告基因小鼠品系 p16-tdT，通过检测不同年龄段各器官中tdT的表达，发现tdT + 细胞在不同器官中的类型具有多样性且比例随着年龄的增长显著增加。 同时，这些tdT + 细胞表现出明显的SA-β-Gal活性、更低的增殖能力及高表达SASP因子等，进一步验证了p16 Ink4a+ 细胞的细胞衰老表型。 图1. 衰老的 p16-tdT 小鼠多种细胞类型表达tdT. 细胞衰老与肝纤维化有相关性，针对肝纤维化这一特定病理过程，研究团队利用四氯化碳（CCl 4）诱导的肝脏 …

2024年11月11日 · p16 Ink4a-positive cells in the brain of chronic subordination stress-exposed mice were primarily hippocampal and cortical neurons with evidence of DNA damage that could be reduced by p16 Ink4a...

P16 INK4A is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. Extensive research has revealed that p16 expression is significantly increased in senescent cells, as well as during natural aging or age-related pathologies.

P16 INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin repeats, is recognized as a tumor suppressor mainly due to the prevalence of genetic inactivation of the p16INK4A (or CDKN2A) gene in virtually all types of human cancers.

2024年12月2日 · Our research indicates that fully senescent p16 INK4A+ cells are rarely identified in the parenchyma of organic tissues and in the stromal cells crucial for structural maintenance, such as...

2025年1月6日 · In a recent Cell issue, Zhao et al. create mouse models to genetically manipulate and trace p16 + cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis. Cellular senescence was first described as an irreversible arrest state with unique cytomorphological features.

1997年11月28日 · Among the most notable of these gene products is the cyclin-dependent kinase inhibitor p16 (also known as CDKN2, MTS-1, and INK4a), implicated in cell cycle regulation and cellular senescence, whose loss results in genetic predisposition to malignant melanoma and pancreatic cancer (for review, seeHall and Peters 1996).

2023年8月31日 · Our results show that the presence of p16 High senescent cells limits cell plasticity, whereas their depletion can promote a totipotent-like state and histopathological tissue rejuvenation...