P16 UV mutations in human skin epithelial tumors - Oncogene
1999年9月23日 · Our data demonstrate for the first time the presence of p16 UV induced mutations in non melanoma skin cancer, particularly in the most aggressive SCC type, and …
P16 UV mutations in human skin epithelial tumors - PubMed
1999年9月23日 · Our data demonstrate for the first time the presence of p16 UV induced mutations in non melanoma skin cancer, particularly in the most aggressive SCC type, and …
Utility of UV Signature Mutations in the Diagnostic Assessment of ...
2024年2月23日 · We identified 14 HR-HPV negative metastatic HNCUP to either the cervical or parotid gland lymph nodes, of which, 11 (11/14, 79%) had UV signature mutations, including 4 …
Our data demonstrate for the ®rst time the presence of p16 UV induced mutations in non melanoma skin cancer, particularly in the most aggressive SCC type, and support that p16 …
The tumor suppressor p16 - Nature
2004年1月8日 · It is clearly shown that p16-compromised osteosarcoma U2OS cell line and p16−/− mouse embryo fibroblasts are sensitive to UV-induced apoptosis, as compared to their …
The Atr Protein Kinase Controls UV-Dependent Upregulation of p16
2011年3月15日 · The tumor suppressor p16 INK4A, a phosphoprotein that exists in human cells under both phosphorylated and nonphosphorylated forms, plays crucial roles during the …
Induced expression of p16 and p21 proteins in UVB
1999年4月1日 · The results revealed an accumulation of p16, p21 and PCNA proteins by UVB exposure, indicating a concomitant protective or adaptive role of these molecules in UVB …
(PDF) P16UV mutations in human skin epithelial tumors
1999年10月1日 · Our data demonstrate for the first time the presence of p16 UV induced mutations in non melanoma skin cancer, particularly in the most aggressive SCC type, and …
Ultraviolet radiation induces p16CDKN2A expression in human skin
1999年9月1日 · In this report, we demonstrate that when human skin was irradiated with suberythemal doses of UV radiation, levels of p16 were dramatically increased by 16 h …
The Regulatory Mechanisms of Tumor Suppressor P16
P16-compromised or P16-deficient cells demonstrated sensitivity to ultraviolet (UV) light-induced apoptosis, suggesting that the absence of functional P16 allows propagation of proapoptotic …