p22phox Protein, also known as the human neutrophil cytochrome b light chain (CYBA), is an essential component of the membrane-associated enzyme phagocyte NADPH-oxidase [1] This enzyme uses NADH or NADPH as the electron donor for the one electron reduction of oxygen to produce superoxide anion, a reactive oxygen species (ROS), [2] and a function...

P22phox also called the α-subunit of the flavocytochrome b558, is composed of 195 amino acids and runs at 22 kDa on SDS-PAGE (Parkos et al., 1988).

P22 phox is a ubiquitous protein encoded by the CYBA gene located on the long arm of chromosome 16 at position 24, containing six exons and spanning 8.5 kb. P22 phox is a critical component of the superoxide-generating nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs).

2010年6月4日 · A p22 phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation of K562 and HEL cells. p22 phox expression was downregulated by RNAi experiments in HEL and K562...

2016年7月15日 · P22 (phox) is a critical component of the superoxide-generating nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs). It is associated with NOX2 to form cytochrome b558 expressed mainly in phagocytes and responsible for the killing of microorganisms when bacterial and fungal infections occur.

2018年2月20日 · The p22 phox protein is an essential component of the phagocytic- and inner ear NADPH oxidases but its relationship to other Nox proteins is less clear. We have studied the role of p22 phox in the TGF-β1-stimulated H 2 O 2 production of …

我们提供的第一个证据表明，p22（phox）是产生超氧化物的血管NADH / NADPH氧化酶的关键成分，并暗示该氧化酶系统在血管肥大中的重要作用。 超氧阴离子的形成对于吞噬细胞的杀微生物活性至关重要。 但是，最近有越来越多的证据表明它也参与血管平滑肌细胞（VSMC）的细胞生长。 我们已经表明，肥大剂血管紧张素II通过激活膜结合的NADH / NADPH氧化酶来刺激超氧化物的产生，并且对该氧化酶的抑制会减弱血管肥大。 但是，尚不清楚该氧化酶在VSMC中的分子身份 …

2016年7月15日 · P22 phox is a ubiquitous protein encoded by the CYBA gene located on the long arm of chromosome 16 at position 24, containing six exons and spanning 8.5 kb. P22 phox is a critical component of the superoxide-generating nicotinamide

2003年5月8日 · The p22 phox subunit is an essential protein in the activation of NAD(P)H oxidase. Here we report the preliminary characterisation of the human p22 phox gene promoter. The p22 phox promoter contains TATA and CCAC boxes and Sp1, γ …

Heterodimers of p22 (phox) and gp91 (phox) proteins constitute the superoxide-producing cytochrome core of the phagocyte NADPH oxidase. In this study, we identified the nmf333 mouse strain as what we believe to be the first animal model of p22 (phox) deficiency.