Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin …

2024年12月24日 · CDKN1B (Cyclin Dependent Kinase Inhibitor 1B) is a Protein Coding gene. Diseases associated with CDKN1B include Multiple Endocrine Neoplasia, Type Iv and Primary …

The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.

2020年9月1日 · p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other processes including cell migration and development independent of its cyclin-dependent …

The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, …

Three features of p27 make it a strong candidate as a target to consider in cancer therapy. First, while not mutated or lost at the gene level, the abundance of the protein has proven to be a …

Mutations, abnormal expression and mislocalization of p27 have been found in many diseases suggesting the important role of p27 in the pathogenesis of diseases. Human p27 gene …

Gene ID: 1027, updated on 9-Feb-2025. This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds …

2018年9月1日 · Transfection of lung cancer cell with the p27 gene through an adenoviral vector leads to cell death and apoptosis. P27 mediates cell cycle arrest and apoptosis via down …

2025年2月8日 · Absence of functional p27(Kip1) gene results in enhanced retinal pigment epithelium nuclear division, without commensurate increase in cell division. Retinal cells …