2022年4月17日 · In the current study, we aimed to analyze whether antibody cross-reactivity between CVB4 P2C and GAD may contribute to the onset of T1D and/or SPS. In total, 12 …

2004年11月1日 · A sequence of six identical amino acids (PEVKEK) is shared by the 2C protein of Coxsackie virus B and the glutamic acid decarboxylase (GAD) molecules. Between 1995 …

The sequence homology between the coxsackie B4 virus nonstructural protein 2C (CVB4 p2C) and the major diabetes autoantigen glutamic acid decarboxylase (GAD(65)) provides a basis …

2021年4月30日 · 对小鼠脑组织切片进行免疫组织化学染色或cba法检测，gad免疫反应阳性提示gad抗体滴度≥1800u/ml（放射免疫分析法定量测定），以线点技术检测，gad免疫反应阳性提 …

icry between protein 2C (p2C) of coxsackie virus B4 and the autoantigen glutamic acid decarboxylase (GAD65) plays a role in the pathogenesis of insulin-dependent diabetes …

2004年12月1日 · Our data showed that the viral p2C sequence with homology with GAD is highly conserved in CVB5 isolates. There was no difference between diabetogenic and non …

It has been proposed that molecular mimicry between protein 2C (p2C) of coxsackie virus B4 and the autoantigen glutamic acid decarboxylase (GAD65) plays a role in the pathogenesis of …

1996年7月15日 · Our study highlights the usefulness of peptides as diagnostic antigens in T1DM and LADA, and extends previous findings by comparing IgM and IgG-isotype antibodies in the …

In the current study, we aimed to analyze whether antibody cross-reactivity between CVB4 P2C and GAD may contribute to the onset of T1D and/or SPS. In total, 12 mice were immunized …

In this study we show that the amino acid sequence of p2C which shares homology with a sequence in GAD65 (PEVKEK), is highly conserved in coxsackie virus B4 isolates as well as …