2022年4月17日 · In the current study, we aimed to analyze whether antibody cross-reactivity between CVB4 P2C and GAD may contribute to the onset of T1D and/or SPS. In total, 12 mice were immunized with peptides originating from GAD65, GAD67, or CVB P2C, and the immune responses of the majority of mice showed some degree of cross-reactivity.

2004年11月1日 · A sequence of six identical amino acids (PEVKEK) is shared by the 2C protein of Coxsackie virus B and the glutamic acid decarboxylase (GAD) molecules. Between 1995 and 2002, we investigated 22 Coxsackie virus B5 (CVB5) isolates from southern Taiwan.

The sequence homology between the coxsackie B4 virus nonstructural protein 2C (CVB4 p2C) and the major diabetes autoantigen glutamic acid decarboxylase (GAD(65)) provides a basis for the hypothesis of molecular mimicry. In this study, we investigated the prevalence of antibodies directed against nonstructural enterovirus proteins.

2021年4月30日 · 对小鼠脑组织切片进行免疫组织化学染色或cba法检测，gad免疫反应阳性提示gad抗体滴度≥1800u/ml（放射免疫分析法定量测定），以线点技术检测，gad免疫反应阳性提示gad抗体滴度≥1400u/ml（放射免疫分析法定量测定）。

icry between protein 2C (p2C) of coxsackie virus B4 and the autoantigen glutamic acid decarboxylase (GAD65) plays a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). In this study we show that the amino acid sequence of p2C which shares homology with a sequence in GAD65 (PE-VKEK), is highly conserved in coxsackie virus B4 iso-

2004年12月1日 · Our data showed that the viral p2C sequence with homology with GAD is highly conserved in CVB5 isolates. There was no difference between diabetogenic and non-diabetogenic CVB5 isolates. All...

It has been proposed that molecular mimicry between protein 2C (p2C) of coxsackie virus B4 and the autoantigen glutamic acid decarboxylase (GAD65) plays a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). In this study we show that the amino acid sequence of p2C which shares ho …

1996年7月15日 · Our study highlights the usefulness of peptides as diagnostic antigens in T1DM and LADA, and extends previous findings by comparing IgM and IgG-isotype antibodies in the same population. Additionally, results highlight the role of the entourage in the shared sequon PEVKXK in GAD and CVB4P2C particularly in IgMs identification.

In the current study, we aimed to analyze whether antibody cross-reactivity between CVB4 P2C and GAD may contribute to the onset of T1D and/or SPS. In total, 12 mice were immunized with peptides originating from GAD65, GAD67, or CVB P2C, and the immune responses of the majority of mice showed some degree of cross-reactivity.

In this study we show that the amino acid sequence of p2C which shares homology with a sequence in GAD65 (PEVKEK), is highly conserved in coxsackie virus B4 isolates as well as in different viruses of the subgroup of coxsackie B-like enteroviruses.