2024年7月1日 · Our results suggest that P4HA2 overexpression is significantly associated with the progression of OSCC, whereas P4HA2 knockdown inhibits the proliferation, migration, and metastasis of OSCC...

2024年12月25日 · P4HA2 (Prolyl 4-Hydroxylase Subunit Alpha 2) is a Protein Coding gene. Diseases associated with P4HA2 include Myopia 25, Autosomal Dominant and Temporal Arteritis. Among its related pathways are Collagen chain trimerization and Extracellular matrix organization.

P4HA2 was identified as a novel causative gene for nonsyndromic high myopia. Suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential therapeutic target and biomarker for breast cancer progression.

2024年6月22日 · Our study reveals a novel regulatory mechanism involving prolyl 4-hydroxylase 2 (P4HA2), which forms a complex with KIF7 and is essential for signal transduction of Hh pathway. We...

2024年4月23日 · Here, we demonstrate that prolyl 4-hydroxylase alpha-2 (P4HA2) binds directly to mTOR and hydroxylates one highly conserved proline 2341 (P2341) within a kinase domain of mTOR, thereby...

Through differential gene expression analysis between the microtumor models with an overlap of hypoxia, partial EMT and migration signatures, we identified prolyl 4-hydroxylase subunit 2 (P4HA2), a hypoxia responsive gene, as a central regulator common to hypoxia, partial EMT and collective migration.

KO of P4ha2 led to an increase in cell migration and invasion, which was reversed upon Yap1 KD. Our study identified a novel regulatory mechanism of YAP1 by which P4HA2-dependent prolyl hydroxylation of YAP1 determines its transcriptional activities and its function in …

2024年10月28日 · Title: P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer. Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.

Prolyl-4-hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has suggested that deregulation of P4HA2 is common in cancer. However, …

We identify P4HA2, known to be important for hypoxic adaptation and collagen biogenesis, as a key regulator of tumor-intrinsic hypoxia, partial EMT and collective migration, which may also serve as potential target to inhibit acquisition of migratory phenotype in breast cancer cells.