2015年10月22日 · This study investigated P50 as a potential biomarker of early AD pathology and found that P50 amplitude predicted CSF status in MCI patients. Amyloid- and p-Tau positive MCI patients showed larger P50 amplitudes for all stimulus conditions relative …

事件相关电位（event-related potential, ERP）是一种特殊的脑诱发电位，通过有意地赋予刺激以特殊的心理意义，利用多个或多样的刺激所引起的脑的电位。 提供的是关于脑的高级功能的信息，多与认知过程相关。

p50听觉erp成分中mlr之后在顶区产生一个幅度较小但较为稳定的正成分,峰值潜伏期在50 ms左右,称为p50,也称为听觉p1。 通过对在猫身上用深部电极记录的P50进行分析,发现P50起源于上行网状结构和丘脑。

MLRs之后就是长潜伏期响应(long-latency responses)，通常的顺序是P50(又叫P1)、N100(又称N1)以及P160(又称P2)，如下图所示。 与视觉N1波形类似，当相邻刺激的间隔减小时，中潜伏期和长潜伏期听觉响应也会变小，而且不应期可能超过1000ms。

P50 differentiates mild AD patients from age-matched con-trols, and may have utility in predicting MCI conversion to dementia (Golob et al., 2002, 2007). The P50 is a positive-going wave peaking approximately 50 ms after the onset of an auditory stimulus. It is produced in primary and secondary auditory cortices, though its amplitude

2015年10月10日 · This study investigated P50 as a potential biomarker of early AD pathology and found that P50 amplitude predicted CSF status in MCI patients. Amyloid- and p-Tau positive MCI patients showed larger P50 amplitudes for all stimulus conditions relative …

Time-locked EEG activity or event-related potential (ERP) helps capture neural activity related to both sensory and cognitive processes. In this article, we attempt to present an overview of the different waveforms of ERP and the major findings in various psychiatric conditions.

2015年10月22日 · We investigated the P50 event-related potential component as a noninvasive biomarker of AD pathology in non-demented elderly. Methods: 36 MCI patients were stratified into amyloid positive (MCI-AD, n=17) and negative (MCI-Other, n=19) groups using CSF levels of …

ERP波形通常用正峰和负峰来描述，并用 P1 、 P2 和N1、N2等这样的符号来表示波形的极性与所在时间段或达到峰值的位置，例如，N1表示波形中的第一个负峰，P2表示第二个正峰。 但要注意的是 相同的符号不等同于任何功能上的相关。 以下简要介绍了经典的ERP成分，旨在为对认知神经心理学研究感兴趣的小伙伴提供参考。 视觉感官反应. C1： 通常起始于刺激后40-60ms，在80-100ms达到峰值。 最大幅值出现在头皮后部的中线电极位置，具有极性变化，来自V1区（初 …

This article reviews the applications of the P50 evoked response to paired auditory stimuli (P50 ERP) in the study and evaluation of cognitive impairments after traumatic brain injury (TBI). The cholinergic hypothesis of cognitive impairment after TBI and the relationship of …